ARHGEF6 - Rho guanine nucleotide exchange factor 6 - human protein (Function)
 
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Protein
Gene
References

 
ARHGEF6 »  Rho guanine nucleotide exchange factor 6
 
Gene name:  ARHGEF6
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 44 2
GENE REF ISO

Function

 show evidences
Overview 
Acts as a RAC1 guanine nucleotide exchange factor (GEF).  
  • CuratedUniProtKB
GO molecular function 
GTPase activator activitydefinition[GO:0005096]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIIntAct
  • IPIUniProtKB
Rho guanyl-nucleotide exchange factor activitydefinition[GO:0005089]  
1
  • NASUniProtKB
GO biological process 
Apoptotic processdefinition[GO:0006915]  
1
  • NASUniProtKB
JNK cascadedefinition[GO:0007254]  
1
  • NASUniProtKB
Lamellipodium assemblydefinition[GO:0030032]  
  • ISSOrtholog Curator
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • NASGOC
Positive regulation of Rho GTPase activitydefinition[GO:0032321]  
1
  • NASGOC
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Pancreatic cancer  hsa05212+9459  
Regulation of actin cytoskeleton  hsa04810+9459  
According to Reactome, this protein belongs to the following pathways:
G alpha (12/13) signalling events  REACT_18407  
NRAGE signals death through JNK  REACT_13638  
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components  REACT_20580  
Rho GTPase cycle  REACT_11051  
 

Keywords

Molecular function 
Guanine-nucleotide releasing factor  definition   [KW-0344]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ARHGEF6
GenomeRNAi: 9459
PRO: PR:Q15052