EIF4H - Eukaryotic translation initiation factor 4H - human protein (Function)
 
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EIF4H »  Eukaryotic translation initiation factor 4H  (eIF-4H)
 
Protein also known as:  Williams-Beuren syndrome chromosomal region 1 protein.
Gene name:  EIF4H
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.  
3
  • UniProtKB
GO molecular function 
Nucleotide bindingdefinition[GO:0000166] silver  
1
  • InterPro 2 GO
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
RNA bindingdefinition[GO:0003723]  
1
  • PINC
Translation factor activity, RNA bindingdefinition[GO:0008135]  
1
  • PINC
Translation initiation factor activitydefinition[GO:0003743]  
1
  • UniProtKB KW
GO biological process 
Regulation of translational initiationdefinition[GO:0006446]  
1
  • PINC
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathways:
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S  R-HSA-72662  
GTP hydrolysis and joining of the 60S ribosomal subunit  R-HSA-72706  
L13a-mediated translational silencing of Ceruloplasmin expression  R-HSA-156827  
Ribosomal scanning and start codon recognition  R-HSA-72702  
Translation initiation complex formation  R-HSA-72649  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Protein biosynthesis  definition   [KW-0648]
Molecular function 
Initiation factor  definition   [KW-0396]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: EIF4H
GenomeRNAi: 7458
PRO: PR:Q15056