KIF14 - Kinesin-like protein KIF14 - human protein (Function)
 
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KIF14 »  Kinesin-like protein KIF14
 
Gene name:  KIF14
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity (By similarity). Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (PubMed24784001, PubMed16648480). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (PubMed16431929). Regulates cell growth through regulation of cell cycle progression and cytokinesis (PubMed24854087). During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1 (PubMed24854087). During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division (By similarity). Also is required for chromosome congression and alignment during mitotic cell cycle process (PubMed15843429). Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules (PubMed23209302).  
8
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • Ortholog Curator
ATP-dependent microtubule motor activity, plus-end-directeddefinition[GO:0008574]  
1
  • Ortholog Curator
ATPase activitydefinition[GO:0016887]  
2
  • RefGenome
  • Ortholog Curator
Microtubule bindingdefinition[GO:0008017]  
1
  • Ortholog Curator
Microtubule motor activitydefinition[GO:0003777]  
1
  • RefGenome
PDZ domain bindingdefinition[GO:0030165]  
1
  • MGI
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901]  
2
  • UniProtKB
Tubulin bindingdefinition[GO:0015631]  
1
  • Ortholog Curator
GO biological process 
Activation of protein kinase activitydefinition[GO:0032147]  
1
  • UniProtKB
Cell proliferation in forebraindefinition[GO:0021846]  
1
  • Ortholog Curator
Cerebellar cortex developmentdefinition[GO:0021695]  
1
  • Ortholog Curator
Cerebellar granular layer structural organizationdefinition[GO:0021685]  
1
  • Ortholog Curator
Cerebellar Purkinje cell layer structural organizationdefinition[GO:0021693]  
1
  • Ortholog Curator
Cerebral cortex developmentdefinition[GO:0021987]  
1
  • Ortholog Curator
Cytoskeleton-dependent intracellular transportdefinition[GO:0030705]  
1
  • RefGenome
Establishment of protein localizationdefinition[GO:0045184]  
1
  • MGI
Hippocampus developmentdefinition[GO:0021766]  
1
  • Ortholog Curator
Not  Microtubule depolymerizationdefinition[GO:0007019]  
1
  • Ortholog Curator
Microtubule-based movementdefinition[GO:0007018]  
1
  • RefGenome
Mitotic cell cycle processdefinition[GO:1903047]  
1
  • UniProtKB
Mitotic metaphase plate congressiondefinition[GO:0007080]  
1
  • UniProtKB
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of integrin activationdefinition[GO:0033624]  
1
  • MGI
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
1
  • Ortholog Curator
Olfactory bulb developmentdefinition[GO:0021772]  
1
  • Ortholog Curator
Positive regulation of cell proliferationdefinition[GO:0008284]  
2
  • UniProtKB
Positive regulation of cytokinesisdefinition[GO:0032467]  
2
  • UniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic processdefinition[GO:0043161]  
1
  • UniProtKB
Regulation of cell adhesiondefinition[GO:0030155]  
1
  • MGI
Regulation of cell growthdefinition[GO:0001558]  
1
  • UniProtKB
Regulation of cell migrationdefinition[GO:0030334]  
1
  • MGI
Regulation of G1/S transition of mitotic cell cycledefinition[GO:2000045]  
1
  • UniProtKB
Regulation of G2/M transition of mitotic cell cycledefinition[GO:0010389]  
1
  • UniProtKB
Regulation of myelinationdefinition[GO:0031641]  
1
  • Ortholog Curator
Regulation of neuron apoptotic processdefinition[GO:0043523]  
1
  • Ortholog Curator
Regulation of Rap protein signal transductiondefinition[GO:0032487]  
1
  • MGI
Not  Response to docetaxel trihydratedefinition[GO:1902519]  
1
  • UniProtKB
SCF-dependent proteasomal ubiquitin-dependent protein catabolic processdefinition[GO:0031146]  
1
  • UniProtKB
Substrate adhesion-dependent cell spreadingdefinition[GO:0034446]  
1
  • MGI
Note 
It is resistant to docetaxel anhydrous.  
2
  • UniProtKB
 

Keywords

Molecular function 
Motor protein  definition   [KW-0505]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KIF14
GenomeRNAi: 9928
PRO: PR:Q15058