P2RY6 - P2Y purinoceptor 6 - human protein (Function)
 
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Protein
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P2RY6 »  P2Y purinoceptor 6  (P2Y6)
 
Gene name:  P2RY6
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.  
  • CuratedUniProtKB
GO molecular function 
G-protein coupled purinergic nucleotide receptor activitydefinition[GO:0045028] silver  
  • IEAInterPro 2 GO
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • TASPINC
UDP-activated nucleotide receptor activitydefinition[GO:0045029] silver  
  • IEAOrtholog Compara
GO biological process 
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200]  
1
  • TASPINC
Positive regulation of smooth muscle cell migrationdefinition[GO:0014911] silver  
  • IEAOrtholog Compara
Transepithelial chloride transportdefinition[GO:0030321] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+5031  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: P2RY6
GenomeRNAi: 5031
PRO: PR:Q15077
Chemistry
GuidetoPHARMACOLOGY: 326