Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
In order to isolate new subtypes of P2Y purinoceptors, a human placenta cDNA library was screened at middle stringency with a P2Y4 probe. The purification and the sequencing of several clones led us to identify a 984 base pair open reading frame encoding a new human P2Y receptor. It appeared later that this sequence corresponds to the human ortholog (88% amino acid identity) of the rat receptor recently cloned by Chang et al (J. Biol. Chem. 270, 26152-26158, 1995) and called P2Y6. Northern blot analysis detected human P2Y6 receptor messenger RNA in human spleen, placenta, thymus, intestine, and blood leukocytes. In 1321N1 cells stably expressing the human P2Y6 receptor, the formation of IP3 was stimulated by nucleotides with the following order of potency: UDP > 5-bromo-UPT > UTP > ADP > 2-methylthio-ATP >> ATP. The P2Y6 receptor, together with the previously cloned P2Y4 subtype (Communi et al., J. Biol. Chem., 270, 30849-30852, 1995), belongs thus to a subfamily of pyrimidinoceptors inside the P2Y family.
The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
In order to isolate new subtypes of P2Y purinoceptors, a human placenta cDNA library was screened at middle stringency with a P2Y4 probe. The purification and the sequencing of several clones led us to identify a 984 base pair open reading frame encoding a new human P2Y receptor. It appeared later that this sequence corresponds to the human ortholog (88% amino acid identity) of the rat receptor recently cloned by Chang et al (J. Biol. Chem. 270, 26152-26158, 1995) and called P2Y6. Northern blot analysis detected human P2Y6 receptor messenger RNA in human spleen, placenta, thymus, intestine, and blood leukocytes. In 1321N1 cells stably expressing the human P2Y6 receptor, the formation of IP3 was stimulated by nucleotides with the following order of potency: UDP > 5-bromo-UPT > UTP > ADP > 2-methylthio-ATP >> ATP. The P2Y6 receptor, together with the previously cloned P2Y4 subtype (Communi et al., J. Biol. Chem., 270, 30849-30852, 1995), belongs thus to a subfamily of pyrimidinoceptors inside the P2Y family.
Receptors which transduce extracellular signals across the cell membrane. At the external side they receive a ligand (a photon in case of opsins), and at the cytosolic side they activate a guanine nucleotide-binding (G) protein. These receptors are hydrophobic proteins that cross the membrane seven times.
A reference proteome is a set of protein sequences derived from a complete proteome which constitutes a defined standard for a particular user community. Reference proteomes are manually defined according to a number of criteria. They cover the proteomes of well- studied model organisms and other proteomes of interest for biomedical and biotechnological research. Reference proteomes have been selected to provide broad coverage of the tree of life, and constitute a representative cross-section of the taxonomic diversity to be found within UniProtKB.
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