NCF4 - Neutrophil cytosol factor 4 - human protein (Function)
 
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Protein
Gene
References

 
NCF4 »  Neutrophil cytosol factor 4  (NCF-4)
 
Protein also known as:  SH3 and PX domain-containing protein 4.
Gene name:  NCF4
Entry whose protein(s) existence is based on evidence at protein level
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1 51 3
GENE REF ISO

Function

 show evidences
Overview 
Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.  
1
  • CuratedUniProtKB
GO molecular function 
Phosphatidylinositol-3-phosphate bindingdefinition[GO:0032266]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • IPIIntAct
  • IPIUniProtKB
Protein dimerization activitydefinition[GO:0046983]  
1
  • TASUniProtKB
Superoxide-generating NADPH oxidase activator activitydefinition[GO:0016176]  
1
  • IMPUniProtKB
GO biological process 
Immune responsedefinition[GO:0006955]  
1
  • TASUniProtKB
Oxidation-reduction processdefinition[GO:0055114]  
1
  • TASUniProtKB
Positive regulation of catalytic activitydefinition[GO:0043085]  
1
  • IMPGOC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Leishmaniasis  hsa05140+4689  
Leukocyte transendothelial migration  hsa04670+4689  
Osteoclast differentiation  hsa04380+4689  
Phagosome  hsa04145+4689  
According to Reactome, this protein belongs to the following pathways:
Cross-presentation of particulate exogenous antigens (phagosomes)  REACT_111174  
Phagosomal maturation (early endosomal stage)  REACT_121256  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 4689
PRO: PR:Q15080