PDIA6 - Protein disulfide-isomerase A6 - human protein (Function)
 
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PDIA6 »  Protein disulfide-isomerase A6   [ EC 5.3.4.1 ]
 
Protein also known as:  Thioredoxin domain-containing protein 7.
Gene name:  PDIA6
Entry whose protein(s) existence is based on evidence at protein level
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1 41 3
GENE REF ISO

Function

 show evidences
Overview 
May function as a chaperone that inhibits aggregation of misfolded proteins. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Protein disulfide isomerase activitydefinition[GO:0003756] silver  
  • IBARefGenome
Protein disulfide oxidoreductase activitydefinition[GO:0015035] silver  
  • IEAInterPro 2 GO
GO biological process 
Apoptotic cell clearancedefinition[GO:0043277] silver  
  • IBARefGenome
Cell redox homeostasisdefinition[GO:0045454] silver  
  • IEAInterPro 2 GO
Glycerol ether metabolic processdefinition[GO:0006662] silver  
  • IEAInterPro 2 GO
Protein foldingdefinition[GO:0006457] silver  
  • IBARefGenome
Response to endoplasmic reticulum stressdefinition[GO:0034976] silver  
  • IBARefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.3.4.1: Catalyzes the rearrangement of -S-S- bonds in proteins.  
2
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Protein processing in endoplasmic reticulum  hsa04141+10130  
According to Reactome, this protein belongs to the following pathway:
Metabolism of proteins  REACT_17015  
 

Keywords

Molecular function 
Chaperone  definition   [KW-0143]
Isomerase  definition   [KW-0413]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 10130
PRO: PR:Q15084