AGER - Advanced glycosylation end product-specific receptor - human protein (Function)
 
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AGER »  Advanced glycosylation end product-specific receptor
 
Protein also known as:  Receptor for advanced glycosylation end products.
Gene name:  AGER
Entry whose protein(s) existence is based on evidence at protein level
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7 541 10
GENE REF ISO

Function

 show evidences
Overview 
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.  
5
  • UniProtKB
GO molecular function 
Advanced glycation end-product receptor activitydefinition[GO:0050785] silver  
1
  • Ortholog Compara
High mobility group box 1 bindingdefinition[GO:0070379] silver  
1
  • Ortholog Compara
Identical protein bindingdefinition[GO:0042802]  
1
  • IntAct
Protein bindingdefinition[GO:0005515]  
10
  • IntAct
  • UniProtKB
Receptor activitydefinition[GO:0004872]  
1
  • PINC
S100 protein bindingdefinition[GO:0044548]  
1
  • UniProtKB
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • PINC
GO biological process 
Brain developmentdefinition[GO:0007420] silver  
1
  • Ortholog Compara
Calcium ion homeostasisdefinition[GO:0055074] silver  
1
  • Ortholog Compara
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • PINC
Cellular response to drugdefinition[GO:0035690] silver  
1
  • Ortholog Compara
Cellular response to fatty aciddefinition[GO:0071398] silver  
1
  • Ortholog Compara
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
1
  • Ortholog Compara
Cellular response to hydrogen peroxidedefinition[GO:0070301] silver  
1
  • Ortholog Compara
Cellular response to organic cyclic compounddefinition[GO:0071407] silver  
1
  • Ortholog Compara
Glycoprotein metabolic processdefinition[GO:0009100] silver  
1
  • Ortholog Compara
Induction of positive chemotaxisdefinition[GO:0050930] silver  
1
  • Ortholog Compara
Inflammatory responsedefinition[GO:0006954] silver  
1
  • Ortholog Compara
JAK-STAT cascadedefinition[GO:0007259] silver  
1
  • Ortholog Compara
Lung developmentdefinition[GO:0030324] silver  
1
  • Ortholog Compara
Negative regulation of cell adhesiondefinition[GO:0007162] silver  
1
  • Ortholog Compara
Negative regulation of collagen biosynthetic processdefinition[GO:0032966] silver  
1
  • Ortholog Compara
Negative regulation of endothelial cell migrationdefinition[GO:0010596] silver  
1
  • Ortholog Compara
Negative regulation of endothelial cell proliferationdefinition[GO:0001937] silver  
1
  • Ortholog Compara
Negative regulation of osteoblast proliferationdefinition[GO:0033689] silver  
1
  • Ortholog Compara
Negative regulation of protein phosphorylationdefinition[GO:0001933] silver  
1
  • Ortholog Compara
Neuron projection developmentdefinition[GO:0031175]  
1
  • UniProtKB
Positive regulation of autophagydefinition[GO:0010508] silver  
1
  • Ortholog Compara
Positive regulation of endothelial cell apoptotic processdefinition[GO:2000353] silver  
1
  • Ortholog Compara
Positive regulation of epithelial to mesenchymal transitiondefinition[GO:0010718] silver  
1
  • Ortholog Compara
Positive regulation of fibroblast migrationdefinition[GO:0010763] silver  
1
  • Ortholog Compara
Positive regulation of fibroblast proliferationdefinition[GO:0048146] silver  
1
  • Ortholog Compara
Positive regulation of inflammatory responsedefinition[GO:0050729] silver  
1
  • Ortholog Compara
Positive regulation of JUN kinase activitydefinition[GO:0043507] silver  
1
  • Ortholog Compara
Positive regulation of neuron apoptotic processdefinition[GO:0043525] silver  
1
  • Ortholog Compara
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • UniProtKB
Positive regulation of phagocytosis, engulfmentdefinition[GO:0060100] silver  
1
  • Ortholog Compara
Positive regulation of potassium ion transmembrane transporter activitydefinition[GO:1901018] silver  
1
  • Ortholog Compara
Positive regulation of reactive oxygen species metabolic processdefinition[GO:2000379] silver  
1
  • Ortholog Compara
Positive regulation of smooth muscle cell migrationdefinition[GO:0014911] silver  
1
  • Ortholog Compara
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661] silver  
1
  • Ortholog Compara
Positive regulation of type B pancreatic cell apoptotic processdefinition[GO:2000676] silver  
1
  • Ortholog Compara
Protein localization to membranedefinition[GO:0072657] silver  
1
  • Ortholog Compara
Regulation of DNA bindingdefinition[GO:0051101] silver  
1
  • Ortholog Compara
Response to activitydefinition[GO:0014823] silver  
1
  • Ortholog Compara
Response to fructosedefinition[GO:0009750] silver  
1
  • Ortholog Compara
Response to genisteindefinition[GO:0033595] silver  
1
  • Ortholog Compara
Response to hyperoxiadefinition[GO:0055093] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to methylglyoxaldefinition[GO:0051595] silver  
1
  • Ortholog Compara
Response to selenite iondefinition[GO:0072714] silver  
1
  • Ortholog Compara
Response to vitamin Adefinition[GO:0033189] silver  
1
  • Ortholog Compara
Response to woundingdefinition[GO:0009611]  
1
  • PINC
Transdifferentiationdefinition[GO:0060290] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Advanced glycosylation endproduct receptor signaling  R-HSA-879415  
DEx/H-box helicases activate type I IFN and inflammatory cytokines production  R-HSA-3134963  
RIP-mediated NFkB activation via ZBP1  R-HSA-1810476  
TAK1 activates NFkB by phosphorylation and activation of IKKs complex  R-HSA-445989  
TRAF6 mediated NF-kB activation  R-HSA-933542  
 

Keywords

Biological process 
Inflammatory response  definition   [KW-0395]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: RAGE_(receptor)
GenomeRNAi: 177
PRO: PR:Q15109
Chemistry
GuidetoPHARMACOLOGY: 2843