AGER - Advanced glycosylation end product-specific receptor - human protein (Function)
 
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AGER »  Advanced glycosylation end product-specific receptor
 
Protein also known as:  Receptor for advanced glycosylation end products.
Gene name:  AGER
Entry whose protein(s) existence is based on evidence at protein level
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1 435 9
GENE REF ISO

Function

 show evidences
Overview 
Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.  
4
  • CuratedUniProtKB
GO molecular function 
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Protein bindingdefinition[GO:0005515]  
8
  • IPIIntAct
  • IPIUniProtKB
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
S100 protein bindingdefinition[GO:0044548]  
1
  • IPIUniProtKB
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • TASPINC
GO biological process 
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • TASPINC
Induction of positive chemotaxisdefinition[GO:0050930] silver  
  • IEAOrtholog Compara
Inflammatory responsedefinition[GO:0006954]  
  • IEAUniProtKB KW
Neuron projection developmentdefinition[GO:0031175]  
1
  • IGIUniProtKB
Positive regulation of NF-kappaB transcription factor activitydefinition[GO:0051092]  
1
  • IDAUniProtKB
Response to woundingdefinition[GO:0009611]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Inflammatory response  definition   [KW-0395]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: RAGE_(receptor)
GenomeRNAi: 177
PRO: PR:Q15109