PDK1 - [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial - human protein (Function)
 
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PDK1 »  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial   [ EC 2.7.11.2 ]
 
Protein also known as:  Pyruvate dehydrogenase kinase isoform 1 (PDH kinase 1).
Gene name:  PDK1
Entry whose protein(s) existence is based on evidence at protein level
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1 32 1
GENE REF ISO

Function

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Overview 
Serine/threonine kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.  
4
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein kinase activitydefinition[GO:0004672]  
1
  • IDAUniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
  • IEAUniProtKB KW
Pyruvate dehydrogenase (acetyl-transferring) kinase activitydefinition[GO:0004740]  
2
  • IMPUniProtKB
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • IMPUniProtKB
Glucose metabolic processdefinition[GO:0006006]  
  • IEAUniProtKB KW
Hypoxia-inducible factor-1alpha signaling pathwaydefinition[GO:0097411]  
1
  • IMPUniProtKB
Intrinsic apoptotic signaling pathway in response to oxidative stressdefinition[GO:0008631]  
1
  • IMPUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
3
  • IMPGOC
Regulation of glucose metabolic processdefinition[GO:0010906]  
1
  • IMPUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.2: ATP + [pyruvate dehydrogenase (acetyl-transferring)] ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.  
3
  • CuratedUniProtKB
It is regulated in the following manner
Activity is enhanced by binding to the pyruvate dehydrogenase subunit DLAT. Inhibited by AZD7545; this compound interferes with DLAT binding and thereby inhibits kinase activity. Inhibited by dichloroacetate and radicicol.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Fc epsilon RI signaling pathway  hsa04664+5163  
Hepatitis C  hsa05160+5163  
Neurotrophin signaling pathway  hsa04722+5163  
T cell receptor signaling pathway  hsa04660+5163  
Toxoplasmosis  hsa05145+5163  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Glucose metabolism  definition   [KW-0313]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links