PDK3 - [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial - human protein (Function)
 
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PDK3 »  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial   [ EC 2.7.11.2 ]
 
Protein also known as:  Pyruvate dehydrogenase kinase isoform 3.
Gene name:  PDK3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 29 2
GENE REF ISO

Function

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Overview 
Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species.  
8
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Protein kinase activitydefinition[GO:0004672]  
1
  • UniProtKB
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • UniProtKB
Pyruvate dehydrogenase (acetyl-transferring) kinase activitydefinition[GO:0004740]  
1
  • UniProtKB
GO biological process 
Cellular response to fatty aciddefinition[GO:0071398]  
1
  • UniProtKB
Cellular response to glucose stimulusdefinition[GO:0071333]  
1
  • Ortholog Curator
Glucose metabolic processdefinition[GO:0006006]  
1
  • UniProtKB KW
Hypoxia-inducible factor-1alpha signaling pathwaydefinition[GO:0097411]  
1
  • UniProtKB
Peptidyl-serine phosphorylationdefinition[GO:0018105]  
1
  • UniProtKB
Peroxisome proliferator activated receptor signaling pathwaydefinition[GO:0035357]  
1
  • UniProtKB
Regulation of acetyl-CoA biosynthetic process from pyruvatedefinition[GO:0010510]  
1
  • UniProtKB
Regulation of glucose metabolic processdefinition[GO:0010906]  
1
  • UniProtKB
Regulation of reactive oxygen species metabolic processdefinition[GO:2000377]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.2: ATP + [pyruvate dehydrogenase (acetyl-transferring)] ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.  
4
  • UniProtKB
It is regulated in the following manner
Activated by interaction with DLAT. Inhibited by AZD7545, dichloroacetate and radicicol.  
3
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathways:
Regulation of pyruvate dehydrogenase (PDH) complex  REACT_12528  
Signaling by Retinoic Acid  REACT_267785  
 

Keywords

Biological process 
Carbohydrate metabolism  definition   [KW-0119]
Glucose metabolism  definition   [KW-0313]
Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PDK3
GenomeRNAi: 5165
PRO: PR:Q15120