CDK10 - Cyclin-dependent kinase 10 - human protein (Function)
 
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CDK10 »  Cyclin-dependent kinase 10   [ EC 2.7.11.22 ]
 
Protein also known as:  Serine/threonine-protein kinase PISSLRE.
Gene name:  CDK10
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells).  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Cyclin-dependent protein serine/threonine kinase activitydefinition[GO:0004693]  
1
  • EC 2 GO
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
GO biological process 
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • PINC
Positive regulation of MAPK cascadedefinition[GO:0043410] silver  
1
  • Ortholog Compara
Protein phosphorylationdefinition[GO:0006468] silver  
1
  • InterPro 2 GO
Traversing start control point of mitotic cell cycledefinition[GO:0007089]  
1
  • PINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.22: ATP + a protein ADP + a phosphoprotein.  
2
  • UniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Cyclin-dependent_kinase_10
GenomeRNAi: 8558
PRO: PR:Q15131