PLCB4 - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 - human protein (Function)
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PLCB4 »  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4   [ EC ]
Protein also known as:  Phosphoinositide phospholipase C-beta-4.
Gene name:  PLCB4
Entry whose protein(s) existence is based on evidence at protein level
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The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Phosphatidylinositol phospholipase C activitydefinition[GO:0004435]  
  • IEAEC 2 GO
Phospholipase C activitydefinition[GO:0004629]  
Signal transducer activitydefinition[GO:0004871]  
  • IEAUniProtKB KW
GO biological process 
Intracellular signal transductiondefinition[GO:0035556] silver  
  • IEAInterPro 2 GO
Lipid catabolic processdefinition[GO:0016042]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.  
  • CuratedUniProtKB
It requires the following cofactor
  • CuratedUniProtKB
According to KEGG, this protein belongs to the following pathways:
African trypanosomiasis  hsa05143+5332  
Alzheimer's disease  hsa05010+5332  
Amoebiasis  hsa05146+5332  
Calcium signaling pathway  hsa04020+5332  
Chagas disease (American trypanosomiasis)  hsa05142+5332  
Chemokine signaling pathway  hsa04062+5332  
Cholinergic synapse  hsa04725+5332  
Dopaminergic synapse  hsa04728+5332  
Endocrine and other factor-regulated calcium reabsorption  hsa04961+5332  
Gap junction  hsa04540+5332  
Gastric acid secretion  hsa04971+5332  
Glutamatergic synapse  hsa04724+5332  
GnRH signaling pathway  hsa04912+5332  
Huntington's disease  hsa05016+5332  
Inositol phosphate metabolism  hsa00562+5332  
Long-term depression  hsa04730+5332  
Long-term potentiation  hsa04720+5332  
Melanogenesis  hsa04916+5332  
Metabolic pathways  hsa01100+5332  
Pancreatic secretion  hsa04972+5332  
Phosphatidylinositol signaling system  hsa04070+5332  
Salivary secretion  hsa04970+5332  
Vascular smooth muscle contraction  hsa04270+5332  
Wnt signaling pathway  hsa04310+5332  
According to Reactome, this protein belongs to the following pathways:
G alpha (q) signalling events  REACT_18283  
PLC beta mediated events  REACT_15426  
Synthesis of IP3 and IP4 in the cytosol  REACT_150312  


Biological process 
Lipid degradation  definition   [KW-0442]
Lipid metabolism  definition   [KW-0443]
Molecular function 
Hydrolase  definition   [KW-0378]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: PLCB4
GenomeRNAi: 5332
PRO: PR:Q15147