IRF4 - Interferon regulatory factor 4 - human protein (Function)
 
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Protein
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References

 
IRF4 »  Interferon regulatory factor 4  (IRF-4)
 
Protein also known as:  Lymphocyte-specific interferon regulatory factor (LSIRF).
Gene name:  IRF4
Family name: IRF
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 34 2
GENE REF ISO

Function

 show evidences
Overview 
Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and activation of genes (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein-lysine N-methyltransferase activitydefinition[GO:0016279] silver  
  • IEAOrtholog Compara
Regulatory region DNA bindingdefinition[GO:0000975] silver  
  • IEAInterPro 2 GO
Sequence-specific DNA bindingdefinition[GO:0043565]  
  • ISSOrtholog Curator
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • NASUniProtKB
  • ISSOrtholog Curator
Transcription factor bindingdefinition[GO:0008134]  
1
  • NASUniProtKB
GO biological process 
Defense response to protozoandefinition[GO:0042832]  
  • ISSOrtholog Curator
Histone H3 acetylationdefinition[GO:0043966] silver  
  • IEAOrtholog Compara
Histone H4 acetylationdefinition[GO:0043967] silver  
  • IEAOrtholog Compara
Myeloid dendritic cell differentiationdefinition[GO:0043011] silver  
  • IEAOrtholog Compara
Negative regulation of toll-like receptor signaling pathwaydefinition[GO:0034122] silver  
  • IEAOrtholog Compara
Positive regulation of DNA bindingdefinition[GO:0043388] silver  
  • IEAOrtholog Compara
Positive regulation of interleukin-10 biosynthetic processdefinition[GO:0045082]  
1
  • IDAUniProtKB
Positive regulation of interleukin-13 biosynthetic processdefinition[GO:0045368]  
1
  • IDAUniProtKB
Positive regulation of interleukin-2 biosynthetic processdefinition[GO:0045086]  
1
  • IDAUniProtKB
Positive regulation of interleukin-4 biosynthetic processdefinition[GO:0045404]  
1
  • IDAUniProtKB
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Regulation of T-helper cell differentiationdefinition[GO:0045622]  
1
  • NASUniProtKB
T cell activationdefinition[GO:0042110]  
1
  • NASUniProtKB
T-helper 17 cell lineage commitmentdefinition[GO:0072540]  
  • ISSOrtholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IRF4
GenomeRNAi: 3662
PRO: PR:Q15306