E2F5 - Transcription factor E2F5 - human protein (Function)
 
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E2F5 »  Transcription factor E2F5  (E2F-5)
 
Gene name:  E2F5
Family name: E2F/DP
Entry whose protein(s) existence is based on evidence at protein level
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1 24 3
GENE REF ISO

Function

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Overview 
Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
  • IEAOrtholog Compara
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIUniProtKB
GO biological process 
Organ morphogenesisdefinition[GO:0009887] silver  
  • IEAOrtholog Compara
Regulation of cell cycledefinition[GO:0051726] silver  
  • IEAInterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell cycle  hsa04110+1875  
TGF-beta signaling pathway  hsa04350+1875  
According to Reactome, this protein belongs to the following pathways:
Cyclin D associated events in G1  REACT_821  
G0 and Early G1  REACT_111214  
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription  REACT_120734  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: E2F5
GenomeRNAi: 1875
PRO: PR:Q15329