LLGL1 - Lethal(2) giant larvae protein homolog 1 - human protein (Function)
 
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LLGL1 »  Lethal(2) giant larvae protein homolog 1  (LLGL)
 
Protein also known as:  Human homolog to the D-lgl gene protein.
Gene name:  LLGL1
Family name: WD repeat L(2)GL
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 33 1
GENE REF ISO

Function

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Overview 
Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.  
3
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • UniProtKB
Rab GTPase activator activitydefinition[GO:0005097]  
1
  • Ortholog Curator
Structural molecule activitydefinition[GO:0005198]  
1
  • PINC
GO biological process 
Axonogenesisdefinition[GO:0007409]  
1
  • Ortholog Curator
Cortical actin cytoskeleton organizationdefinition[GO:0030866]  
1
  • UniProtKB
Exocytosisdefinition[GO:0006887]  
1
  • UniProtKB KW
Golgi to plasma membrane transportdefinition[GO:0006893]  
1
  • Ortholog Curator
Maintenance of apical/basal cell polaritydefinition[GO:0035090] silver  
1
  • Ortholog Compara
Positive regulation of Rab GTPase activitydefinition[GO:0032851]  
1
  • Ortholog Curator
Protein complex assemblydefinition[GO:0006461]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Tight junction  hsa04530+3996  
Note 
Down-regulation of LLGL1 is associated with the progression of colorectal cancer and melanoma. Located within the Smith-Magenis syndrome region on chromosome 17; deleted in patients with this syndrome.  
1
  • UniProtKB
Expression increases cell adhesion and decreases cell migration. Substitutes for Drosophila l(2)gl tumor suppressor function in vivo.  
1
  • UniProtKB
 

Keywords

Biological process 
Exocytosis  definition   [KW-0268]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: LLGL1
GenomeRNAi: 3996
PRO: PR:Q15334