RPS6KA2 - Ribosomal protein S6 kinase alpha-2 - human protein (Function)
 
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RPS6KA2 »  Ribosomal protein S6 kinase alpha-2   [ EC 2.7.11.1 ]  (S6K-alpha-2)
 
Protein also known as:  MAP kinase-activated protein kinase 1c (MAPKAPK-1c).
Gene name:  RPS6KA2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 39 3
GENE REF ISO

Function

 show evidences
Overview 
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Magnesium ion bindingdefinition[GO:0000287] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • TASPINC
Ribosomal protein S6 kinase activitydefinition[GO:0004711] silver  
  • IEAOrtholog Compara
GO biological process 
Brain renin-angiotensin systemdefinition[GO:0002035] silver  
  • IEAOrtholog Compara
Cardiac muscle cell apoptotic processdefinition[GO:0010659] silver  
  • IEAOrtholog Compara
Cellular response to carbohydrate stimulusdefinition[GO:0071322] silver  
  • IEAOrtholog Compara
Heart contractiondefinition[GO:0060047] silver  
  • IEAOrtholog Compara
Heart developmentdefinition[GO:0007507] silver  
  • IEAOrtholog Compara
Intracellular signal transductiondefinition[GO:0035556]  
2
  • TASPINC
Negative regulation of cell cycledefinition[GO:0045786]  
1
  • IDAUniProtKB
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IDAUniProtKB
Negative regulation of meiosisdefinition[GO:0045835] silver  
  • IEAOrtholog Compara
Oocyte maturationdefinition[GO:0001556] silver  
  • IEAOrtholog Compara
Peptidyl-serine phosphorylationdefinition[GO:0018105] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065]  
1
  • IDAUniProtKB
Positive regulation of gene expressiondefinition[GO:0010628] silver  
  • IEAOrtholog Compara
Regulation of protein processingdefinition[GO:0070613] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • NASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
It is regulated in the following manner
Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-570 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-377, allowing binding of PDPK1, which in turn phosphorylates Ser-218 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Long-term potentiation  hsa04720+6196  
MAPK signaling pathway  hsa04010+6196  
mTOR signaling pathway  hsa04150+6196  
Neurotrophin signaling pathway  hsa04722+6196  
Oocyte meiosis  hsa04114+6196  
Progesterone-mediated oocyte maturation  hsa04914+6196  
According to Reactome, this protein belongs to the following pathways:
Cellular responses to stress  REACT_120956  
Developmental Biology  REACT_111045  
Immune System  REACT_6900  
Neuronal System  REACT_13685  
Signal Transduction  REACT_111102  
TRAF6 Mediated Induction of proinflammatory cytokines  REACT_6782  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: RPS6KA2
GenomeRNAi: 6196
PRO: PR:Q15349
Chemistry
GuidetoPHARMACOLOGY: 1529