EPHA7 - Ephrin type-A receptor 7 - human protein (Function)
 
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EPHA7 »  Ephrin type-A receptor 7   [ EC 2.7.10.1 ]
 
Protein also known as:  EPH homology kinase 3 (EHK-3).
Gene name:  EPHA7
Entry whose protein(s) existence is based on evidence at protein level
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1 56 5
GENE REF ISO

Function

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Overview 
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Axon guidance receptor activitydefinition[GO:0008046]  
  • ISSOrtholog Curator
Chemorepellent activitydefinition[GO:0045499]  
  • ISSOrtholog Curator
Ephrin receptor bindingdefinition[GO:0046875] silver  
  • IEAOrtholog Compara
GPI-linked ephrin receptor activitydefinition[GO:0005004]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein tyrosine kinase activitydefinition[GO:0004713]  
  • ISSOrtholog Curator
GO biological process 
Brain developmentdefinition[GO:0007420]  
  • ISSOrtholog Curator
Branching morphogenesis of a nervedefinition[GO:0048755]  
  • ISSOrtholog Curator
Ephrin receptor signaling pathwaydefinition[GO:0048013]  
1
  • IDAUniProtKB
Negative chemotaxisdefinition[GO:0050919]  
  • ISSOrtholog Curator
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
  • IEAUniProtKB KW
  • IEAEC 2 GO
  • IEAInterPro 2 GO
  • IEAOrtholog Compara
  • ISSOrtholog Curator
Phosphorylationdefinition[GO:0016310]  
  • ISSOrtholog Curator
Positive regulation of neuron apoptotic processdefinition[GO:0043525]  
  • ISSOrtholog Curator
Regulation of cell-cell adhesiondefinition[GO:0022407]  
  • ISSOrtholog Curator
Regulation of cysteine-type endopeptidase activity involved in apoptotic processdefinition[GO:0043281]  
  • ISSOrtholog Curator
Regulation of ERK1 and ERK2 cascadedefinition[GO:0070372]  
1
  • IDAUniProtKB
Regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050730]  
1
  • IDAUniProtKB
Regulation of protein autophosphorylationdefinition[GO:0031952]  
  • ISSOrtholog Curator
Retinal ganglion cell axon guidancedefinition[GO:0031290] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+2045  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Neurogenesis  definition   [KW-0524]
Molecular function 
Developmental protein  definition   [KW-0217]
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: EPHA7
GenomeRNAi: 2045
PRO: PR:Q15375
Chemistry
GuidetoPHARMACOLOGY: 1827