TOMM20 - Mitochondrial import receptor subunit TOM20 homolog - human protein (Function)
 
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TOMM20 »  Mitochondrial import receptor subunit TOM20 homolog
 
Protein also known as:  Outer mitochondrial membrane receptor Tom20.
Gene name:  TOMM20
Family name: Tom20
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).  
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  • UniProtKB
GO molecular function 
Mitochondrion targeting sequence bindingdefinition[GO:0030943]  
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  • RefGenome
P-P-bond-hydrolysis-driven protein transmembrane transporter activitydefinition[GO:0015450]  
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  • HGNC
Protein bindingdefinition[GO:0005515]  
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  • UniProtKB
  • HGNC
Contributes to protein channel activitydefinition[GO:0015266]  
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  • RefGenome
Unfolded protein bindingdefinition[GO:0051082]  
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  • HGNC
GO biological process 
Mitochondrial outer membrane translocase complex assemblydefinition[GO:0070096]  
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  • RefGenome
Protein import into mitochondrial matrixdefinition[GO:0030150]  
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  • RefGenome
Protein targeting to mitochondriondefinition[GO:0006626]  
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  • HGNC
tRNA import into mitochondriondefinition[GO:0016031]  
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  • RefGenome
Pathways 
According to Reactome, this protein belongs to the following pathways:
Mitochondrial protein import  R-HSA-1268020  
Pink/Parkin Mediated Mitophagy  R-HSA-5205685  
 

Keywords

Biological process 
Protein transport  definition   [KW-0653]
Transport  definition   [KW-0813]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TOMM20
GenomeRNAi: 9804
PRO: PR:Q15388