ANGPT1 - Angiopoietin-1 - human protein (Function)
 
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ANGPT1 »  Angiopoietin-1  (ANG-1)
 
Gene name:  ANGPT1
Entry whose protein(s) existence is based on evidence at protein level
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1 50 2
GENE REF ISO

Function

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Overview 
Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.  
4
  • CuratedUniProtKB
GO molecular function 
Receptor tyrosine kinase bindingdefinition[GO:0030971]  
2
  • IPIUniProtKB
GO biological process 
Activation of transmembrane receptor protein tyrosine kinase activitydefinition[GO:0007171]  
1
  • IDAUniProtKB
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Cell-substrate adhesiondefinition[GO:0031589] silver  
  • IEAOrtholog Compara
Glomerulus vasculature developmentdefinition[GO:0072012]  
  • ISSOrtholog Curator
Hemopoiesisdefinition[GO:0030097] silver  
  • IEAOrtholog Compara
Heparin biosynthetic processdefinition[GO:0030210]  
1
  • IDAUniProtKB
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
2
  • IDAUniProtKB
Negative regulation of cell adhesiondefinition[GO:0007162]  
1
  • IDAUniProtKB
Negative regulation of endothelial cell apoptotic processdefinition[GO:2000352]  
1
  • IDAUniProtKB
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Negative regulation of vascular permeabilitydefinition[GO:0043116]  
2
  • IDAUniProtKB
Positive chemotaxisdefinition[GO:0050918]  
1
  • IDAUniProtKB
Positive regulation of blood vessel endothelial cell migrationdefinition[GO:0043536]  
1
  • IDAUniProtKB
Positive regulation of cell adhesiondefinition[GO:0045785] silver  
  • IEAOrtholog Compara
Positive regulation of endothelial cell migrationdefinition[GO:0010595]  
1
  • IDAUniProtKB
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
2
  • IDAUniProtKB
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138] silver  
  • IEAOrtholog Compara
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
2
  • IDAUniProtKB
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068] silver  
  • IEAOrtholog Compara
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
2
  • IDAUniProtKB
Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
1
  • IDAUniProtKB
Positive regulation of receptor internalizationdefinition[GO:0002092]  
1
  • IDAUniProtKB
Protein localization to cell surfacedefinition[GO:0034394]  
1
  • IDAUniProtKB
Not  Regulation of endothelial cell proliferationdefinition[GO:0001936]  
1
  • IDAUniProtKB
Regulation of satellite cell proliferationdefinition[GO:0014842]  
1
  • IDAUniProtKB
Sprouting angiogenesisdefinition[GO:0002040]  
2
  • IDAUniProtKB
Tie signaling pathwaydefinition[GO:0048014]  
2
  • IDAUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Rheumatoid arthritis  hsa05323+284  
According to Reactome, this protein belongs to the following pathway:
Tie2 Signaling  REACT_12621  
Note 
It may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Differentiation  definition   [KW-0221]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Angiopoietin_1
GenomeRNAi: 284
PRO: PR:Q15389