ANGPT1 - Angiopoietin-1 - human protein (Function)
 
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ANGPT1 »  Angiopoietin-1  (ANG-1)
 
Gene name:  ANGPT1
Entry whose protein(s) existence is based on evidence at protein level
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1 53 2
GENE REF ISO

Function

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Overview 
Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.  
5
  • UniProtKB
GO molecular function 
Receptor tyrosine kinase bindingdefinition[GO:0030971]  
2
  • UniProtKB
GO biological process 
Activation of transmembrane receptor protein tyrosine kinase activitydefinition[GO:0007171]  
1
  • UniProtKB
Cell differentiationdefinition[GO:0030154]  
1
  • UniProtKB KW
Cell-substrate adhesiondefinition[GO:0031589] silver  
1
  • Ortholog Compara
Glomerulus vasculature developmentdefinition[GO:0072012]  
1
  • Ortholog Curator
Hemopoiesisdefinition[GO:0030097] silver  
1
  • Ortholog Compara
Heparin biosynthetic processdefinition[GO:0030210]  
1
  • UniProtKB
In utero embryonic developmentdefinition[GO:0001701] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
2
  • UniProtKB
Negative regulation of cell adhesiondefinition[GO:0007162]  
1
  • UniProtKB
Negative regulation of endothelial cell apoptotic processdefinition[GO:2000352]  
1
  • UniProtKB
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Negative regulation of vascular permeabilitydefinition[GO:0043116]  
2
  • UniProtKB
Positive chemotaxisdefinition[GO:0050918]  
1
  • UniProtKB
Positive regulation of blood vessel endothelial cell migrationdefinition[GO:0043536]  
1
  • UniProtKB
Positive regulation of cell adhesiondefinition[GO:0045785] silver  
1
  • Ortholog Compara
Positive regulation of endothelial cell migrationdefinition[GO:0010595]  
1
  • UniProtKB
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
2
  • UniProtKB
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138] silver  
1
  • Ortholog Compara
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731]  
2
  • UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068] silver  
1
  • Ortholog Compara
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
2
  • UniProtKB
Positive regulation of protein ubiquitinationdefinition[GO:0031398]  
1
  • UniProtKB
Positive regulation of receptor internalizationdefinition[GO:0002092]  
1
  • UniProtKB
Protein localization to cell surfacedefinition[GO:0034394]  
1
  • UniProtKB
Not  Regulation of endothelial cell proliferationdefinition[GO:0001936]  
1
  • UniProtKB
Regulation of satellite cell proliferationdefinition[GO:0014842]  
1
  • UniProtKB
Sprouting angiogenesisdefinition[GO:0002040]  
2
  • UniProtKB
Tie signaling pathwaydefinition[GO:0048014]  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Rheumatoid arthritis  hsa05323+284  
According to Reactome, this protein belongs to the following pathway:
Tie2 Signaling  REACT_12621  
Note 
It may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart.  
1
  • UniProtKB
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Differentiation  definition   [KW-0221]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Angiopoietin_1
GenomeRNAi: 284
PRO: PR:Q15389