TLR1 - Toll-like receptor 1 - human protein (Function)
 
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Protein
Gene
References

 
TLR1 »  Toll-like receptor 1
 
Protein also known as:  Toll/interleukin-1 receptor-like protein (TIL); CD antigen CD281.
Gene name:  TLR1
Family name: Toll-like receptor
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).  
1
  • UniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • UniProtKB
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • MGI
Receptor activitydefinition[GO:0004872]  
1
  • PINC
Toll-like receptor 2 bindingdefinition[GO:0035663]  
1
  • UniProtKB
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • UniProtKB
GO biological process 
Cellular response to triacyl bacterial lipopeptidedefinition[GO:0071727]  
2
  • MGI
  • UniProtKB
Detection of triacyl bacterial lipopeptidedefinition[GO:0042495]  
1
  • MGI
Immune responsedefinition[GO:0006955]  
1
  • PINC
Inflammatory responsedefinition[GO:0006954]  
1
  • UniProtKB KW
Macrophage activationdefinition[GO:0042116]  
1
  • UniProtKB
Positive regulation of interleukin-6 biosynthetic processdefinition[GO:0045410]  
1
  • UniProtKB
Positive regulation of tumor necrosis factor biosynthetic processdefinition[GO:0042535]  
1
  • UniProtKB
Regulation of cytokine secretiondefinition[GO:0050707] silver  
1
  • InterPro 2 GO
Signal transductiondefinition[GO:0007165]  
2
  • PINC
Toll-like receptor 1 signaling pathwaydefinition[GO:0034130] silver  
1
  • InterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathways:
Toll-like receptor signaling pathway  hsa04620+7096  
Tuberculosis  hsa05152+7096  
According to Reactome, this protein belongs to the following pathways:
Beta defensins  R-HSA-1461957  
IRAK4 deficiency (TLR2/4)  R-HSA-5603041  
MyD88 deficiency (TLR2/4)  R-HSA-5602498  
MyD88:Mal cascade initiated on plasma membrane  R-HSA-166058  
Toll Like Receptor TLR1:TLR2 Cascade  R-HSA-168179  
 

Keywords

Biological process 
Immunity  definition   [KW-0391]
Inflammatory response  definition   [KW-0395]
Innate immunity  definition   [KW-0399]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TLR_1
GenomeRNAi: 7096
PRO: PR:Q15399