SHB - SH2 domain-containing adapter protein B - human protein (Function)
 
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Protein
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References

 
SHB »  SH2 domain-containing adapter protein B
 
Gene name:  SHB
Entry whose protein(s) existence is based on evidence at protein level
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1 37 2
GENE REF ISO

Function

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Overview 
Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.  
10
  • CuratedUniProtKB
GO molecular function 
Glycoprotein bindingdefinition[GO:0001948] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
SH3/SH2 adaptor activitydefinition[GO:0005070]  
1
  • TASPINC
GO biological process 
Angiogenesisdefinition[GO:0001525]  
  • IEAUniProtKB KW
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
B cell proliferationdefinition[GO:0042100] silver  
  • IEAOrtholog Compara
Cell differentiationdefinition[GO:0030154]  
  • IEAUniProtKB KW
Hemopoiesisdefinition[GO:0030097] silver  
  • IEAOrtholog Compara
Negative regulation of oocyte maturationdefinition[GO:1900194] silver  
  • IEAOrtholog Compara
Positive regulation of signal transductiondefinition[GO:0009967]  
1
  • TASGOC
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Apoptosis  definition   [KW-0053]
Differentiation  definition   [KW-0221]
Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SHB_(gene)
GenomeRNAi: 6461
PRO: PR:Q15464