NR0B2 - Nuclear receptor subfamily 0 group B member 2 - human protein (Function)
 
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NR0B2 »  Nuclear receptor subfamily 0 group B member 2
 
Protein also known as:  Orphan nuclear receptor SHP.
Gene name:  NR0B2
Family name: Nuclear hormone receptor » NR0
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 88 1
GENE REF ISO

Function

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Overview 
Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.  
2
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677] silver  
1
  • InterPro 2 GO
Peroxisome proliferator activated receptor bindingdefinition[GO:0042975] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
5
  • IntAct
  • UniProtKB
Protein complex bindingdefinition[GO:0032403] silver  
1
  • Ortholog Compara
Protein domain specific bindingdefinition[GO:0019904]  
1
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
Retinoid X receptor bindingdefinition[GO:0046965] silver  
1
  • Ortholog Compara
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700] silver  
1
  • InterPro 2 GO
Steroid hormone receptor activitydefinition[GO:0003707] silver  
1
  • InterPro 2 GO
Thyroid hormone receptor bindingdefinition[GO:0046966] silver  
1
  • Ortholog Compara
Transcription corepressor activitydefinition[GO:0003714]  
1
  • UniProtKB
GO biological process 
Cholesterol metabolic processdefinition[GO:0008203]  
1
  • PINC
Negative regulation of gene expressiondefinition[GO:0010629]  
1
  • UniProtKB
Negative regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0043433]  
1
  • UniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Organ regenerationdefinition[GO:0031100] silver  
1
  • Ortholog Compara
Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • UniProtKB
Positive regulation of insulin secretiondefinition[GO:0032024] silver  
1
  • Ortholog Compara
Response to glucosedefinition[GO:0009749] silver  
1
  • Ortholog Compara
Steroid hormone mediated signaling pathwaydefinition[GO:0043401] silver  
1
  • InterPro 2 GO
Pathways 
According to KEGG, this protein belongs to the following pathway:
Bile secretion  hsa04976+8431  
According to Reactome, this protein belongs to the following pathway:
Nuclear Receptor transcription pathway  REACT_15525  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Receptor  definition   [KW-0675]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Small_heterodimer_partner
GenomeRNAi: 8431
PRO: PR:Q15466