STIL - SCL-interrupting locus protein - human protein (Function)
 
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STIL »  SCL-interrupting locus protein
 
Protein also known as:  TAL-1-interrupting locus protein.
Gene name:  STIL
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1.  
2
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
GO biological process 
Cell proliferationdefinition[GO:0008283]  
1
  • TASPINC
Determination of left/right symmetrydefinition[GO:0007368]  
  • ISSOrtholog Curator
Embryonic axis specificationdefinition[GO:0000578]  
  • ISSOrtholog Curator
Floor plate developmentdefinition[GO:0033504]  
  • ISSOrtholog Curator
Forebrain developmentdefinition[GO:0030900]  
  • ISSOrtholog Curator
Heart loopingdefinition[GO:0001947]  
  • ISSOrtholog Curator
In utero embryonic developmentdefinition[GO:0001701]  
  • ISSOrtholog Curator
Multicellular organism growthdefinition[GO:0035264]  
  • ISSOrtholog Curator
Negative regulation of apoptotic processdefinition[GO:0043066]  
  • ISSOrtholog Curator
Neural tube closuredefinition[GO:0001843]  
  • ISSOrtholog Curator
Neural tube developmentdefinition[GO:0021915]  
  • ISSOrtholog Curator
Notochord developmentdefinition[GO:0030903]  
  • ISSOrtholog Curator
Smoothened signaling pathwaydefinition[GO:0007224]  
  • ISSOrtholog Curator
 

Keywords

Molecular function 
Developmental protein  definition   [KW-0217]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: STIL
GenomeRNAi: 6491
PRO: PR:Q15468