SIX1 - Homeobox protein SIX1 - human protein (Function)
 
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SIX1 »  Homeobox protein SIX1
 
Protein also known as:  Sine oculis homeobox homolog 1.
Gene name:  SIX1
Entry whose protein(s) existence is based on evidence at protein level
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1 57 1
GENE REF ISO

Function

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Overview 
Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1.  
5
  • UniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
1
  • Ortholog Compara
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • UniProtKB
  • IntAct
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
2
  • NTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
2
  • NTNU_SB
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • UniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • UniProtKB
  • Ortholog Curator
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • UniProtKB
GO biological process 
Aorta morphogenesisdefinition[GO:0035909] silver  
1
  • Ortholog Compara
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB KW
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658]  
1
  • Ortholog Curator
Cochlea morphogenesisdefinition[GO:0090103] silver  
1
  • Ortholog Compara
Embryonic cranial skeleton morphogenesisdefinition[GO:0048701]  
1
  • Ortholog Curator
Embryonic skeletal system morphogenesisdefinition[GO:0048704]  
1
  • Ortholog Curator
Epithelial cell differentiationdefinition[GO:0030855]  
1
  • Ortholog Curator
Facial nerve morphogenesisdefinition[GO:0021610] silver  
1
  • Ortholog Compara
Generation of neuronsdefinition[GO:0048699]  
1
  • Ortholog Curator
Inner ear developmentdefinition[GO:0048839]  
1
  • Ortholog Curator
Inner ear morphogenesisdefinition[GO:0042472]  
1
  • Ortholog Curator
Kidney developmentdefinition[GO:0001822]  
1
  • Ortholog Curator
Mesonephric tubule formationdefinition[GO:0072172]  
1
  • Ortholog Curator
Metanephric mesenchyme developmentdefinition[GO:0072075]  
1
  • Ortholog Curator
Middle ear morphogenesisdefinition[GO:0042474] silver  
1
  • Ortholog Compara
Myoblast migrationdefinition[GO:0051451]  
1
  • Ortholog Curator
Negative regulation of branching involved in ureteric bud morphogenesisdefinition[GO:0090191] silver  
1
  • Ortholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
1
  • Ortholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Neuron fate specificationdefinition[GO:0048665] silver  
1
  • Ortholog Compara
Organ inductiondefinition[GO:0001759]  
1
  • Ortholog Curator
Otic vesicle developmentdefinition[GO:0071599] silver  
1
  • Ortholog Compara
Outflow tract morphogenesisdefinition[GO:0003151] silver  
1
  • Ortholog Compara
Pattern specification processdefinition[GO:0007389]  
1
  • Ortholog Curator
Pharyngeal system developmentdefinition[GO:0060037] silver  
1
  • Ortholog Compara
Positive regulation of branching involved in ureteric bud morphogenesisdefinition[GO:0090190]  
1
  • Ortholog Curator
Positive regulation of mesenchymal cell proliferation involved in ureter developmentdefinition[GO:2000729] silver  
1
  • Ortholog Compara
Positive regulation of secondary heart field cardioblast proliferationdefinition[GO:0072513] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • UniProtKB
  • NTNU_SB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • Ortholog Curator
Positive regulation of ureteric bud formationdefinition[GO:0072107]  
1
  • Ortholog Curator
Protein localization to nucleusdefinition[GO:0034504]  
1
  • UniProtKB
Regulation of branch elongation involved in ureteric bud branchingdefinition[GO:0072095]  
1
  • Ortholog Curator
Regulation of neuron differentiationdefinition[GO:0045664]  
1
  • Ortholog Curator
Regulation of protein localizationdefinition[GO:0032880] silver  
1
  • Ortholog Compara
Regulation of synaptic growth at neuromuscular junctiondefinition[GO:0008582] silver  
1
  • Ortholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
1
  • Ortholog Curator
Sensory perception of sounddefinition[GO:0007605] silver  
1
  • Ortholog Compara
Skeletal muscle tissue developmentdefinition[GO:0007519]  
1
  • Ortholog Curator
Thymus developmentdefinition[GO:0048538]  
1
  • Ortholog Curator
Thyroid gland developmentdefinition[GO:0030878]  
1
  • Ortholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
1
  • UniProtKB KW
Ureter smooth muscle cell differentiationdefinition[GO:0072193] silver  
1
  • Ortholog Compara
Ureteric bud developmentdefinition[GO:0001657]  
1
  • Ortholog Curator
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SIX1
GenomeRNAi: 6495
PRO: PR:Q15475