SIX1 - Homeobox protein SIX1 - human protein (Function)
 
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SIX1 »  Homeobox protein SIX1
 
Protein also known as:  Sine oculis homeobox homolog 1.
Gene name:  SIX1
Entry whose protein(s) existence is based on evidence at protein level
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1 54 1
GENE REF ISO

Function

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Overview 
Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1.  
4
  • CuratedUniProtKB
GO molecular function 
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
DNA bindingdefinition[GO:0003677]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
  • IPIIntAct
Sequence-specific DNA bindingdefinition[GO:0043565]  
1
  • IDAUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDAUniProtKB
  • ISSOrtholog Curator
Transcription regulatory region DNA bindingdefinition[GO:0044212]  
1
  • IDAUniProtKB
GO biological process 
Aorta morphogenesisdefinition[GO:0035909] silver  
  • IEAOrtholog Compara
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Branching involved in ureteric bud morphogenesisdefinition[GO:0001658]  
  • ISSOrtholog Curator
Cochlea morphogenesisdefinition[GO:0090103] silver  
  • IEAOrtholog Compara
Embryonic cranial skeleton morphogenesisdefinition[GO:0048701]  
  • ISSOrtholog Curator
Embryonic skeletal system morphogenesisdefinition[GO:0048704]  
  • ISSOrtholog Curator
Epithelial cell differentiationdefinition[GO:0030855]  
  • ISSOrtholog Curator
Facial nerve morphogenesisdefinition[GO:0021610] silver  
  • IEAOrtholog Compara
Generation of neuronsdefinition[GO:0048699]  
  • ISSOrtholog Curator
Inner ear developmentdefinition[GO:0048839]  
  • ISSOrtholog Curator
Inner ear morphogenesisdefinition[GO:0042472]  
  • ISSOrtholog Curator
Kidney developmentdefinition[GO:0001822]  
  • ISSOrtholog Curator
Mesonephric tubule formationdefinition[GO:0072172]  
  • ISSOrtholog Curator
Metanephric mesenchyme developmentdefinition[GO:0072075]  
  • ISSOrtholog Curator
Middle ear morphogenesisdefinition[GO:0042474] silver  
  • IEAOrtholog Compara
Myoblast migrationdefinition[GO:0051451]  
  • ISSOrtholog Curator
Negative regulation of branching involved in ureteric bud morphogenesisdefinition[GO:0090191] silver  
  • IEAOrtholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
  • ISSOrtholog Curator
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Neuron fate specificationdefinition[GO:0048665] silver  
  • IEAOrtholog Compara
Organ inductiondefinition[GO:0001759]  
  • ISSOrtholog Curator
Otic vesicle developmentdefinition[GO:0071599] silver  
  • IEAOrtholog Compara
Outflow tract morphogenesisdefinition[GO:0003151] silver  
  • IEAOrtholog Compara
Pattern specification processdefinition[GO:0007389]  
  • ISSOrtholog Curator
Pharyngeal system developmentdefinition[GO:0060037] silver  
  • IEAOrtholog Compara
Positive regulation of branching involved in ureteric bud morphogenesisdefinition[GO:0090190]  
  • ISSOrtholog Curator
Positive regulation of mesenchymal cell proliferation involved in ureter developmentdefinition[GO:2000729] silver  
  • IEAOrtholog Compara
Positive regulation of secondary heart field cardioblast proliferationdefinition[GO:0072513] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDAUniProtKB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Positive regulation of ureteric bud formationdefinition[GO:0072107]  
  • ISSOrtholog Curator
Protein localization to nucleusdefinition[GO:0034504]  
1
  • IDAUniProtKB
Regulation of branch elongation involved in ureteric bud branchingdefinition[GO:0072095]  
  • ISSOrtholog Curator
Regulation of neuron differentiationdefinition[GO:0045664]  
  • ISSOrtholog Curator
Regulation of protein localizationdefinition[GO:0032880] silver  
  • IEAOrtholog Compara
Regulation of synaptic growth at neuromuscular junctiondefinition[GO:0008582] silver  
  • IEAOrtholog Compara
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • ISSOrtholog Curator
Sensory perception of sounddefinition[GO:0007605] silver  
  • IEAOrtholog Compara
Skeletal muscle tissue developmentdefinition[GO:0007519]  
  • ISSOrtholog Curator
Thymus developmentdefinition[GO:0048538]  
  • ISSOrtholog Curator
Thyroid gland developmentdefinition[GO:0030878]  
  • ISSOrtholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Ureter smooth muscle cell differentiationdefinition[GO:0072193] silver  
  • IEAOrtholog Compara
Ureteric bud developmentdefinition[GO:0001657]  
  • ISSOrtholog Curator
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SIX1
GenomeRNAi: 6495
PRO: PR:Q15475