TESK1 - Dual specificity testis-specific protein kinase 1 - human protein (Function)
 
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TESK1 »  Dual specificity testis-specific protein kinase 1   [ EC 2.7.12.1 ]
 
Protein also known as:  Testicular protein kinase 1.
Gene name:  TESK1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 22 1
GENE REF ISO

Function

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Overview 
Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity).  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein serine/threonine kinase activitydefinition[GO:0004674] silver  
  • IEAOrtholog Compara
Protein serine/threonine/tyrosine kinase activitydefinition[GO:0004712]  
  • IEAEC 2 GO
Protein tyrosine kinase activitydefinition[GO:0004713]  
  • IEAUniProtKB KW
GO biological process 
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
  • IEAUniProtKB KW
  • IEAInterPro 2 GO
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.12.1: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactors
Magnesium (By similarity).  
  • CuratedUniProtKB
Manganese (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by autophosphorylation on Ser-220. Kinase activity is inhibited by SPRED1 (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components  REACT_20580  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: TESK1
GenomeRNAi: 7016
PRO: PR:Q15569
Chemistry
GuidetoPHARMACOLOGY: 2239