TGFBI - Transforming growth factor-beta-induced protein ig-h3 - human protein (Function)
 
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TGFBI »  Transforming growth factor-beta-induced protein ig-h3  (Beta ig-h3)
 
Protein also known as:  RGD-containing collagen-associated protein (RGD-CAP).
Gene name:  TGFBI
Entry whose protein(s) existence is based on evidence at protein level
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1 184 1
GENE REF ISO

Function

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Overview 
Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation.  
  • CuratedUniProtKB
GO molecular function 
Collagen bindingdefinition[GO:0005518]  
1
  • IPIBHF-UCL
Extracellular matrix bindingdefinition[GO:0050840] silver  
  • IEAOrtholog Compara
Integrin bindingdefinition[GO:0005178]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • IEPUniProtKB
Cell adhesiondefinition[GO:0007155] silver  
  • IEAOrtholog Compara
Cell proliferationdefinition[GO:0008283]  
1
  • TASPINC
Chondrocyte differentiationdefinition[GO:0002062] silver  
  • IEAOrtholog Compara
Extracellular matrix organizationdefinition[GO:0030198] silver  
  • IEAOrtholog Compara
Negative regulation of cell adhesiondefinition[GO:0007162]  
1
  • TASPINC
Response to stimulusdefinition[GO:0050896]  
  • IEAUniProtKB KW
Visual perceptiondefinition[GO:0007601]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
Amyloids  REACT_75925  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Sensory transduction  definition   [KW-0716]
Vision  definition   [KW-0844]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: TGFBI
GenomeRNAi: 7045
PRO: PR:Q15582