SLC9A3R2 - Na(+)/H(+) exchange regulatory cofactor NHE-RF2 - human protein (Function)
 
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References

 
SLC9A3R2 »  Na(+)/H(+) exchange regulatory cofactor NHE-RF2  (NHERF-2)
 
Protein also known as:  Solute carrier family 9 isoform A3 regulatory factor 2.
Gene name:  SLC9A3R2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed18829453). May also act as scaffold protein in the nucleus.  
4
  • UniProtKB
According to TCDB this is a transporter from family:
the ezrin/radixin/moesin-binding phosphoprotein 50 (ebp50) family  8.A.24.1.2  
GO molecular function 
Beta-catenin bindingdefinition[GO:0008013]  
1
  • UniProtKB
Channel regulator activitydefinition[GO:0016247] silver  
1
  • Ortholog Compara
Low-density lipoprotein particle receptor bindingdefinition[GO:0050750] silver  
1
  • Ortholog Compara
PDZ domain bindingdefinition[GO:0030165] silver  
1
  • Ortholog Compara
Phosphatase bindingdefinition[GO:0019902]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
11
  • UniProtKB
  • IntAct
  • BHF-UCL
Protein C-terminus bindingdefinition[GO:0008022]  
1
  • UniProtKB
Protein complex scaffolddefinition[GO:0032947] silver  
1
  • Ortholog Compara
Receptor bindingdefinition[GO:0005102]  
1
  • UniProtKB
GO biological process 
Inner ear developmentdefinition[GO:0048839] silver  
1
  • Ortholog Compara
Positive regulation of membrane potentialdefinition[GO:0045838] silver  
1
  • Ortholog Compara
Protein complex assemblydefinition[GO:0006461]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Aldosterone-regulated sodium reabsorption  hsa04960+9351  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 9351
PRO: PR:Q15599