ALX1 - ALX homeobox protein 1 - human protein (Function)
 
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Protein
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ALX1 »  ALX homeobox protein 1
 
Protein also known as:  Cartilage homeoprotein 1 (CART-1).
Gene name:  ALX1
Family name: Paired homeobox
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcriptional activator that acts at a palindromic recognition sequence to enhance the activity of the SV40 and TK promoters. Functions as a repressor with the prolactin promoter in vivo. May play a role in chondrocyte differentiation and may also influence cervix development.  
1
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
1
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982] silver  
  • IEAOrtholog Compara
RNA polymerase II regulatory region sequence-specific DNA bindingdefinition[GO:0000977]  
1
  • IDANTNU_SB
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001228]  
1
  • IDANTNU_SB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • TASPINC
Transcription corepressor activitydefinition[GO:0003714]  
1
  • TASPINC
GO biological process 
Anterior/posterior pattern specificationdefinition[GO:0009952] silver  
  • IEAOrtholog Compara
Brain developmentdefinition[GO:0007420]  
1
  • TASPINC
Cartilage condensationdefinition[GO:0001502]  
1
  • TASPINC
Embryonic limb morphogenesisdefinition[GO:0030326] silver  
  • IEAOrtholog Compara
Embryonic skeletal system morphogenesisdefinition[GO:0048704] silver  
  • IEAOrtholog Compara
Mesenchymal cell developmentdefinition[GO:0014031] silver  
  • IEAOrtholog Compara
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • IDAMGI
Neural tube closuredefinition[GO:0001843] silver  
  • IEAOrtholog Compara
Palate developmentdefinition[GO:0060021] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDANTNU_SB
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDAUniProtKB
Transcription from RNA polymerase II promoterdefinition[GO:0006366]  
1
  • TASPINC
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Developmental protein  definition   [KW-0217]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ALX1
GenomeRNAi: 8092
PRO: PR:Q15699