DLG2 - Disks large homolog 2 - human protein (Function)
 
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DLG2 »  Disks large homolog 2
 
Protein also known as:  Channel-associated protein of synapse-110 (Chapsyn-110).
Gene name:  DLG2
Family name: MAGUK
Entry whose protein(s) existence is based on evidence at protein level
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1 36 5
GENE REF ISO

Function

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Overview 
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Guanylate kinase activitydefinition[GO:0004385]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
2
  • IPIUniProtKB
  • IPIIntAct
GO biological process 
Negative regulation of phosphatase activitydefinition[GO:0010923]  
1
  • IDAUniProtKB
Nucleotide phosphorylationdefinition[GO:0046939]  
1
  • TASGOC
Sensory perception of paindefinition[GO:0019233] silver  
  • IEAOrtholog Compara
Synaptic transmissiondefinition[GO:0007268] silver  
  • IEAOrtholog Compara
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: DLG2
GenomeRNAi: 1740
PRO: PR:Q15700