ELAVL1 - ELAV-like protein 1 - human protein (Function)
 
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Protein
Gene
References

 
ELAVL1 »  ELAV-like protein 1
 
Protein also known as:  Hu-antigen R (HuR).
Gene name:  ELAVL1
Family name: RRM elav
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 229 1
GENE REF ISO

Function

 show evidences
Overview 
RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA.  
1
  • CuratedUniProtKB
GO molecular function 
AU-rich element bindingdefinition[GO:0017091]  
1
  • IDAUniProtKB
Double-stranded RNA bindingdefinition[GO:0003725]  
1
  • IDAMGI
mRNA 3'-UTR AU-rich region bindingdefinition[GO:0035925]  
1
  • IDAMGI
mRNA 3'-UTR bindingdefinition[GO:0003730]  
  • ISSOrtholog Curator
mRNA bindingdefinition[GO:0003729]  
1
  • TASPINC
Nucleotide bindingdefinition[GO:0000166] silver  
  • IEAInterPro 2 GO
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
RNA bindingdefinition[GO:0003723]  
2
  • IDAMGI
  • IDAUniProtKB
GO biological process 
3'-UTR-mediated mRNA stabilizationdefinition[GO:0070935]  
2
  • IMPUniProtKB
mRNA stabilizationdefinition[GO:0048255]  
2
  • IDAMGI
  • IMPUniProtKB
Multicellular organismal developmentdefinition[GO:0007275]  
1
  • TASPINC
Positive regulation of translationdefinition[GO:0045727]  
1
  • IDAMGI
Regulation of stem cell maintenancedefinition[GO:2000036]  
  • ISSOrtholog Curator
Pathways 
According to Reactome, this protein belongs to the following pathways:
Gene Expression  REACT_71  
Metabolism of RNA  REACT_21257  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ELAVL1
GenomeRNAi: 1994
PRO: PR:Q15717