LTB4R - Leukotriene B4 receptor 1 - human protein (Function)
 
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LTB4R »  Leukotriene B4 receptor 1  (LTB4-R1)
 
Protein also known as:  Chemoattractant receptor-like 1.
Gene name:  LTB4R
Entry whose protein(s) existence is based on evidence at protein level
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1 56 1
GENE REF ISO

Function

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Overview 
Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.13.5  
GO molecular function 
Leukotriene B4 receptor activitydefinition[GO:0001632] silver  
  • IEAOrtholog Compara
Leukotriene receptor activitydefinition[GO:0004974]  
1
  • TASPINC
Nucleotide bindingdefinition[GO:0000166]  
1
  • TASPINC
GO biological process 
Cellular component movementdefinition[GO:0006928]  
1
  • TASPINC
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Immune responsedefinition[GO:0006955]  
1
  • TASPINC
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Muscle contractiondefinition[GO:0006936]  
1
  • TASPINC
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200]  
1
  • TASPINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+1241  
According to Reactome, this protein belongs to the following pathways:
G alpha (q) signalling events  REACT_18283  
Leukotriene receptors  REACT_18302  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Leukotriene_B4_receptor
GenomeRNAi: 1241
PRO: PR:Q15722
Chemistry
GuidetoPHARMACOLOGY: 267