NSDHL - Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating - human protein (Function)
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NSDHL »  Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating   [ EC ]
Protein also known as:  Protein H105e3.
Gene name:  NSDHL
Family name: 3-beta-HSD
Entry whose protein(s) existence is based on evidence at protein level
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Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis.  
  • CuratedUniProtKB
GO molecular function 
3-beta-hydroxy-delta5-steroid dehydrogenase activitydefinition[GO:0003854] silver  
  • IEAInterPro 2 GO
Sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activitydefinition[GO:0047012]  
  • IEAEC 2 GO
GO biological process 
Hair follicle developmentdefinition[GO:0001942] silver  
  • IEAOrtholog Compara
Labyrinthine layer blood vessel developmentdefinition[GO:0060716] silver  
  • IEAOrtholog Compara
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Smoothened signaling pathwaydefinition[GO:0007224] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC A 3-beta-hydroxysteroid-4-alpha-carboxylate + NAD(P)(+) a 3-oxosteroid + CO(2) + NAD(P)H.  
  • CuratedUniProtKB
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+50814  
Steroid biosynthesis  hsa00100+50814  
According to Reactome, this protein belongs to the following pathway:
Cholesterol biosynthesis  REACT_9405  
More information is available from:


Biological process 
Cholesterol biosynthesis  definition   [KW-0152]
Cholesterol metabolism  definition   [KW-0153]
Lipid biosynthesis  definition   [KW-0444]
Lipid metabolism  definition   [KW-0443]
Steroid biosynthesis  definition   [KW-0752]
Steroid metabolism  definition   [KW-0753]
Sterol biosynthesis  definition   [KW-0756]
Sterol metabolism  definition   [KW-1207]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]

Further external links

GeneWiki: NSDHL
GenomeRNAi: 50814
PRO: PR:Q15738