SLC1A5 - Neutral amino acid transporter B(0) - human protein (Function)
 
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SLC1A5 »  Neutral amino acid transporter B(0)  (ATB(0))
 
Protein also known as:  Sodium-dependent neutral amino acid transporter type 2.
Gene name:  SLC1A5
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed10708449, PubMed23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed10051606, PubMed10196349).  
4
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family  2.A.23.3.3  
GO molecular function 
L-glutamine transmembrane transporter activitydefinition[GO:0015186]  
1
  • TASBHF-UCL
L-serine transmembrane transporter activitydefinition[GO:0015194] silver  
  • IEAOrtholog Compara
Neutral amino acid transmembrane transporter activitydefinition[GO:0015175]  
1
  • TASPINC
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
Sodium:dicarboxylate symporter activitydefinition[GO:0017153] silver  
  • IEAInterPro 2 GO
Virus receptor activitydefinition[GO:0001618]  
  • IEAUniProtKB KW
GO biological process 
Amino acid transmembrane transportdefinition[GO:0003333] silver  
  • IEAOrtholog Compara
Dicarboxylic acid transportdefinition[GO:0006835] silver  
  • IEAInterPro 2 GO
Extracellular amino acid transportdefinition[GO:0006860] silver  
  • IEAOrtholog Compara
Glutamine transportdefinition[GO:0006868]  
1
  • TASBHF-UCL
L-serine transportdefinition[GO:0015825] silver  
  • IEAOrtholog Compara
Neutral amino acid transportdefinition[GO:0015804]  
1
  • TASPINC
Response to virusdefinition[GO:0009615]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Protein digestion and absorption  hsa04974+6510  
According to Reactome, this protein belongs to the following pathway:
Amino acid transport across the plasma membrane  REACT_13796  
 

Keywords

Biological process 
Symport  definition   [KW-0769]
Transport  definition   [KW-0813]
Molecular function 
Host cell receptor for virus entry  definition   [KW-1183]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: SLC1A5
GenomeRNAi: 6510
PRO: PR:Q15758
Chemistry
GuidetoPHARMACOLOGY: 874