SMAD2 - Mothers against decapentaplegic homolog 2 - human protein (Function)
 
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SMAD2 »  Mothers against decapentaplegic homolog 2  (MAD homolog 2)
 
Protein also known as:  Mad-related protein 2.
Gene name:  SMAD2
Family name: Dwarfin/SMAD
Entry whose protein(s) existence is based on evidence at protein level
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1 276 2
GENE REF ISO

Function

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Overview 
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.  
5
  • CuratedUniProtKB
GO molecular function 
Activating transcription factor bindingdefinition[GO:0033613]  
1
  • IPIUniProtKB
Chromatin bindingdefinition[GO:0003682] silver  
  • IEAOrtholog Compara
Co-SMAD bindingdefinition[GO:0070410]  
2
  • IPIBHF-UCL
Contributes to DNA bindingdefinition[GO:0003677]  
1
  • IDABHF-UCL
Double-stranded DNA bindingdefinition[GO:0003690]  
  • ISSOrtholog Curator
Enhancer bindingdefinition[GO:0035326]  
1
  • ICBHF-UCL
I-SMAD bindingdefinition[GO:0070411]  
1
  • IPIBHF-UCL
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Phosphatase bindingdefinition[GO:0019902]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
37
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
R-SMAD bindingdefinition[GO:0070412]  
1
  • IPIBHF-UCL
Contributes to sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
2
  • IDABHF-UCL
SMAD bindingdefinition[GO:0046332]  
1
  • IPIUniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIUniProtKB
Transforming growth factor beta receptor bindingdefinition[GO:0005160]  
1
  • IPIBHF-UCL
Transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activitydefinition[GO:0030618]  
2
  • IDABHF-UCL
Type I transforming growth factor beta receptor bindingdefinition[GO:0034713]  
1
  • IPIBHF-UCL
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IPIBHF-UCL
GO biological process 
Activin receptor signaling pathwaydefinition[GO:0032924]  
1
  • IMPBHF-UCL
Anterior/posterior pattern specificationdefinition[GO:0009952]  
  • ISSOrtholog Curator
Cell fate commitmentdefinition[GO:0045165]  
  • ISSOrtholog Curator
Common-partner SMAD protein phosphorylationdefinition[GO:0007182]  
1
  • IDAMGI
Developmental growthdefinition[GO:0048589] silver  
  • IEAOrtholog Compara
Embryonic cranial skeleton morphogenesisdefinition[GO:0048701] silver  
  • IEAOrtholog Compara
Embryonic foregut morphogenesisdefinition[GO:0048617] silver  
  • IEAOrtholog Compara
Endoderm formationdefinition[GO:0001706] silver  
  • IEAOrtholog Compara
Gastrulationdefinition[GO:0007369]  
1
  • TASBHF-UCL
In utero embryonic developmentdefinition[GO:0001701] silver  
  • IEAOrtholog Compara
Insulin secretiondefinition[GO:0030073] silver  
  • IEAOrtholog Compara
Intracellular signal transductiondefinition[GO:0035556]  
  • ISSOrtholog Curator
Lung developmentdefinition[GO:0030324] silver  
  • IEAOrtholog Compara
Mesoderm formationdefinition[GO:0001707]  
  • ISSOrtholog Curator
Negative regulation of cell proliferationdefinition[GO:0008285] silver  
  • IEAOrtholog Compara
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IMPBHF-UCL
Nodal signaling pathwaydefinition[GO:0038092]  
1
  • IMPBHF-UCL
Organ growthdefinition[GO:0035265] silver  
  • IEAOrtholog Compara
Palate developmentdefinition[GO:0060021]  
  • ISSOrtholog Curator
Pancreas developmentdefinition[GO:0031016] silver  
  • IEAOrtholog Compara
Paraxial mesoderm morphogenesisdefinition[GO:0048340]  
  • ISSOrtholog Curator
Pericardium developmentdefinition[GO:0060039] silver  
  • IEAOrtholog Compara
Positive regulation of BMP signaling pathwaydefinition[GO:0030513]  
1
  • IMPBHF-UCL
Positive regulation of epithelial to mesenchymal transitiondefinition[GO:0010718]  
  • ISSOrtholog Curator
Positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetrydefinition[GO:1900224]  
1
  • IMPBHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
  • ISSOrtholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
4
  • IMPBHF-UCL
  • ISSOrtholog Curator
Post-embryonic developmentdefinition[GO:0009791] silver  
  • IEAOrtholog Compara
Primary miRNA processingdefinition[GO:0031053]  
1
  • TASBHF-UCL
Regulation of bindingdefinition[GO:0051098]  
  • ISSOrtholog Curator
Regulation of transforming growth factor beta receptor signaling pathwaydefinition[GO:0017015]  
1
  • IMPBHF-UCL
Response to cholesteroldefinition[GO:0070723]  
1
  • IDABHF-UCL
Response to glucosedefinition[GO:0009749] silver  
  • IEAOrtholog Compara
Signal transduction involved in regulation of gene expressiondefinition[GO:0023019] silver  
  • IEAOrtholog Compara
SMAD protein complex assemblydefinition[GO:0007183]  
1
  • IDABHF-UCL
Transforming growth factor beta receptor signaling pathwaydefinition[GO:0007179]  
4
  • IDABHF-UCL
Ureteric bud developmentdefinition[GO:0001657] silver  
  • IEAOrtholog Compara
Zygotic specification of dorsal/ventral axisdefinition[GO:0007352]  
1
  • IMPBHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adherens junction  hsa04520+4087  
Cell cycle  hsa04110+4087  
Chagas disease (American trypanosomiasis)  hsa05142+4087  
Colorectal cancer  hsa05210+4087  
Endocytosis  hsa04144+4087  
HTLV-I infection  hsa05166+4087  
Pancreatic cancer  hsa05212+4087  
Pathways in cancer  hsa05200+4087  
TGF-beta signaling pathway  hsa04350+4087  
Wnt signaling pathway  hsa04310+4087  
According to Reactome, this protein belongs to the following pathways:
Downregulation of SMAD2/3:SMAD4 transcriptional activity  REACT_121111  
Downregulation of TGF-beta receptor signaling  REACT_120727  
Signaling by Activin  REACT_150238  
Signaling by NODAL  REACT_111057  
SMAD2/3 MH2 Domain Mutants in Cancer  REACT_169165  
SMAD2/3 Phosphorylation Motif Mutants in Cancer  REACT_169103  
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription  REACT_120734  
SMAD4 MH2 Domain Mutants in Cancer  REACT_169107  
TGF-beta receptor signaling activates SMADs  REACT_120850  
TGFBR1 KD Mutants in Cancer  REACT_169263  
Transcriptional regulation of pluripotent stem cells  REACT_200812  
 

Keywords

Biological process 
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links