ITSN1 - Intersectin-1 - human protein (Function)
 
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ITSN1 »  Intersectin-1
 
Protein also known as:  SH3 domain-containing protein 1A.
Gene name:  ITSN1
Entry whose protein(s) existence is based on evidence at protein level
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1 72 13
GENE REF ISO

Function

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Overview 
Acts as guanine nucleotide exchange factor (GEF) specific for the CDC42 GTPase (By similarity). Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR may involve association with DAB2.  
2
  • CuratedUniProtKB
Isoform  Iso 1   Could be involved in brain-specific synaptic vesicle recycling. Inhibits ARHGAP31 activity toward RAC1.  
2
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
1
  • NASUniProtKB
Guanyl-nucleotide exchange factor activitydefinition[GO:0005085]  
1
  • NASUniProtKB
Kinase activator activitydefinition[GO:0019209] silver  
  • IEAOrtholog Compara
Proline-rich region bindingdefinition[GO:0070064]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
10
  • IPIIntAct
  • IPIUniProtKB
Protein complex scaffolddefinition[GO:0032947]  
1
  • IDAUniProtKB
Rho guanyl-nucleotide exchange factor activitydefinition[GO:0005089] silver  
  • IEAInterPro 2 GO
GO biological process 
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Positive regulation of GTPase activitydefinition[GO:0043547]  
1
  • NASGOC
Positive regulation of phosphorylationdefinition[GO:0042327] silver  
  • IEAOrtholog Compara
Positive regulation of protein kinase B signalingdefinition[GO:0051897] silver  
  • IEAOrtholog Compara
Positive regulation of Rho GTPase activitydefinition[GO:0032321]  
  • IEAInterPro 2 GO
Synaptic vesicle endocytosisdefinition[GO:0048488]  
1
  • TASPINC
Pathways 
According to Reactome, this protein belongs to the following pathways:
G alpha (12/13) signalling events  REACT_18407  
NRAGE signals death through JNK  REACT_13638  
Rho GTPase cycle  REACT_11051  
Caution 
Studies in clathrin-mediated endocytosis of ITGB1 and TFR used a siRNA mixture of ISTN1 and ISTN2, and a Dab2 mutant with impaired binding to EH domain-containing proteins EPS15 and ITSN1 suggesting a partially overlapping role of the EH domain-containing proteins (PubMed22648170).  
1
  • CuratedUniProtKB
 

Keywords

Biological process 
Endocytosis  definition   [KW-0254]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ITSN1
GenomeRNAi: 6453
PRO: PR:Q15811