CHRNA2 - Neuronal acetylcholine receptor subunit alpha-2 - human protein (Function)
 
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CHRNA2 »  Neuronal acetylcholine receptor subunit alpha-2
 
Gene name:  CHRNA2
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.  
1
  • UniProtKB
GO molecular function 
Acetylcholine bindingdefinition[GO:0042166] silver  
1
  • Ortholog Compara
Acetylcholine receptor activitydefinition[GO:0015464]  
1
  • UniProtKB
Acetylcholine-activated cation-selective channel activitydefinition[GO:0004889]  
1
  • UniProtKB
Drug bindingdefinition[GO:0008144] silver  
1
  • Ortholog Compara
GO biological process 
Cation transmembrane transportdefinition[GO:0098655]  
3
  • GOC
  • InterPro 2 GO
  • Ortholog Compara
Cation transportdefinition[GO:0006812]  
1
  • GOC
Ion transportdefinition[GO:0006811]  
1
  • UniProtKB
Protein heterooligomerizationdefinition[GO:0051291] silver  
1
  • Ortholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+1135  
According to Reactome, this protein belongs to the following pathways:
Highly calcium permeable nicotinic acetylcholine receptors  REACT_22352  
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors  REACT_22303  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: CHRNA2
GenomeRNAi: 1135
PRO: PR:Q15822
Chemistry
GuidetoPHARMACOLOGY: 463