KCNJ8 - ATP-sensitive inward rectifier potassium channel 8 - human protein (Function)
 
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Protein
Gene
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KCNJ8 »  ATP-sensitive inward rectifier potassium channel 8
 
Protein also known as:  Potassium channel, inwardly rectifying subfamily J member 8.
Gene name:  KCNJ8
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity).  
1
  • UniProtKB
According to TCDB this is a transporter from family:
inward rectifier k(+) channel (irk-c) family  1.A.2.1.13  
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
1
  • Ortholog Compara
ATP-activated inward rectifier potassium channel activitydefinition[GO:0015272]  
1
  • RefGenome
Not  G-protein activated inward rectifier potassium channel activitydefinition[GO:0015467]  
1
  • RefGenome
Inward rectifier potassium channel activitydefinition[GO:0005242]  
1
  • PINC
Sulfonylurea receptor bindingdefinition[GO:0017098] silver  
1
  • Ortholog Compara
GO biological process 
Defense response to virusdefinition[GO:0051607] silver  
1
  • Ortholog Compara
Heart developmentdefinition[GO:0007507] silver  
1
  • Ortholog Compara
Kidney developmentdefinition[GO:0001822] silver  
1
  • Ortholog Compara
Potassium ion importdefinition[GO:0010107]  
1
  • RefGenome
Potassium ion transportdefinition[GO:0006813]  
1
  • PINC
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • RefGenome
Response to exogenous dsRNAdefinition[GO:0043330] silver  
1
  • Ortholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
1
  • Ortholog Compara
Response to pHdefinition[GO:0009268] silver  
1
  • Ortholog Compara
Vasodilationdefinition[GO:0042311] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
ATP sensitive Potassium channels  REACT_75775  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNJ8
GenomeRNAi: 3764
PRO: PR:Q15842
Chemistry
GuidetoPHARMACOLOGY: 441