ADIPOQ - Adiponectin - human protein (Function)
 
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ADIPOQ »  Adiponectin
 
Protein also known as:  Adipocyte, C1q and collagen domain-containing protein.
Gene name:  ADIPOQ
Entry whose protein(s) existence is based on evidence at protein level
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1 1259 1
GENE REF ISO

Function

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Overview 
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.  
1
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
1
  • NASBHF-UCL
Hormone activitydefinition[GO:0005179]  
1
  • IDABHF-UCL
Identical protein bindingdefinition[GO:0042802]  
1
  • TASBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIBHF-UCL
Receptor bindingdefinition[GO:0005102]  
1
  • ISSBHF-UCL
  • ISSOrtholog Curator
Sialic acid bindingdefinition[GO:0033691]  
1
  • IDAUniProtKB
GO biological process 
Adiponectin-activated signaling pathwaydefinition[GO:0033211] silver  
  • IEAOrtholog Compara
Brown fat cell differentiationdefinition[GO:0050873]  
  • ISSOrtholog Curator
Cellular response to cAMPdefinition[GO:0071320] silver  
  • IEAOrtholog Compara
Cellular response to drugdefinition[GO:0035690]  
  • ISSOrtholog Curator
Cellular response to epinephrine stimulusdefinition[GO:0071872] silver  
  • IEAOrtholog Compara
Cellular response to insulin stimulusdefinition[GO:0032869]  
  • ISSOrtholog Curator
Circadian rhythmdefinition[GO:0007623] silver  
  • IEAOrtholog Compara
Detection of oxidative stressdefinition[GO:0070994]  
  • ISSOrtholog Curator
Fatty acid beta-oxidationdefinition[GO:0006635]  
1
  • ISSBHF-UCL
  • ISSOrtholog Curator
Fatty acid oxidationdefinition[GO:0019395]  
  • ISSOrtholog Curator
Generation of precursor metabolites and energydefinition[GO:0006091]  
1
  • TASPINC
Glucose homeostasisdefinition[GO:0042593]  
1
  • ISSBHF-UCL
  • ISSOrtholog Curator
Glucose metabolic processdefinition[GO:0006006]  
1
  • ISSBHF-UCL
  • ISSOrtholog Curator
Low-density lipoprotein particle clearancedefinition[GO:0034383]  
1
  • IDABHF-UCL
Membrane depolarizationdefinition[GO:0051899] silver  
  • IEAOrtholog Compara
Membrane hyperpolarizationdefinition[GO:0060081] silver  
  • IEAOrtholog Compara
Negative regulation of blood pressuredefinition[GO:0045776]  
1
  • IDAUniProtKB
Negative regulation of cell migrationdefinition[GO:0030336]  
  • ISSOrtholog Curator
Negative regulation of DNA biosynthetic processdefinition[GO:2000279]  
1
  • IDAUniProtKB
Negative regulation of ERK1 and ERK2 cascadedefinition[GO:0070373]  
1
  • IDAUniProtKB
Negative regulation of fat cell differentiationdefinition[GO:0045599]  
1
  • IDABHF-UCL
Negative regulation of gluconeogenesisdefinition[GO:0045721]  
1
  • ISSBHF-UCL
Negative regulation of granulocyte differentiationdefinition[GO:0030853]  
1
  • IDABHF-UCL
Negative regulation of heterotypic cell-cell adhesiondefinition[GO:0034115]  
1
  • IDABHF-UCL
Negative regulation of hormone secretiondefinition[GO:0046888] silver  
  • IEAOrtholog Compara
Negative regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043124]  
1
  • IDABHF-UCL
Negative regulation of inflammatory responsedefinition[GO:0050728]  
1
  • NASBHF-UCL
  • ISSOrtholog Curator
Negative regulation of intracellular protein transportdefinition[GO:0090317]  
1
  • IDAUniProtKB
Negative regulation of low-density lipoprotein particle receptor biosynthetic processdefinition[GO:0045715]  
1
  • IDABHF-UCL
Negative regulation of macrophage derived foam cell differentiationdefinition[GO:0010745]  
1
  • IDABHF-UCL
Negative regulation of macrophage differentiationdefinition[GO:0045650]  
1
  • IDABHF-UCL
Negative regulation of MAP kinase activitydefinition[GO:0043407]  
  • ISSOrtholog Curator
Negative regulation of metanephric mesenchymal cell migrationdefinition[GO:2000590]  
  • ISSOrtholog Curator
Negative regulation of phagocytosisdefinition[GO:0050765]  
1
  • IDABHF-UCL
Negative regulation of platelet-derived growth factor receptor signaling pathwaydefinition[GO:0010642]  
1
  • IDAUniProtKB
Negative regulation of platelet-derived growth factor receptor-alpha signaling pathwaydefinition[GO:2000584]  
  • ISSOrtholog Curator
Negative regulation of protein autophosphorylationdefinition[GO:0031953]  
1
  • IDAUniProtKB
Negative regulation of receptor bindingdefinition[GO:1900121]  
1
  • IDAUniProtKB
Negative regulation of smooth muscle cell migrationdefinition[GO:0014912]  
1
  • IDAUniProtKB
Negative regulation of smooth muscle cell proliferationdefinition[GO:0048662]  
1
  • IDAUniProtKB
Negative regulation of synaptic transmissiondefinition[GO:0050805]  
1
  • IDAUniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
1
  • IDAUniProtKB
Negative regulation of tumor necrosis factor productiondefinition[GO:0032720]  
1
  • IDABHF-UCL
Negative regulation of tumor necrosis factor-mediated signaling pathwaydefinition[GO:0010804]  
1
  • IDABHF-UCL
Positive regulation of blood pressuredefinition[GO:0045777] silver  
  • IEAOrtholog Compara
Positive regulation of cAMP-dependent protein kinase activitydefinition[GO:2000481]  
2
  • IDAUniProtKB
Positive regulation of cellular protein metabolic processdefinition[GO:0032270]  
1
  • IDABHF-UCL
Positive regulation of cholesterol effluxdefinition[GO:0010875]  
1
  • IDABHF-UCL
Positive regulation of fatty acid metabolic processdefinition[GO:0045923]  
1
  • ISSBHF-UCL
Positive regulation of glucose importdefinition[GO:0046326]  
1
  • ISSBHF-UCL
Positive regulation of glycogen (starch) synthase activitydefinition[GO:2000467]  
  • ISSOrtholog Curator
Positive regulation of I-kappaB kinase/NF-kappaB signalingdefinition[GO:0043123]  
  • ISSOrtholog Curator
Positive regulation of interleukin-8 productiondefinition[GO:0032757]  
1
  • IDAUniProtKB
Positive regulation of metanephric glomerular visceral epithelial cell developmentdefinition[GO:2000478]  
  • ISSOrtholog Curator
Positive regulation of monocyte chemotactic protein-1 productiondefinition[GO:0071639]  
1
  • IDAUniProtKB
Positive regulation of myeloid cell apoptotic processdefinition[GO:0033034]  
1
  • IDABHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylationdefinition[GO:0050731] silver  
  • IEAOrtholog Compara
Positive regulation of protein kinase A signalingdefinition[GO:0010739]  
1
  • IDABHF-UCL
Positive regulation of protein phosphorylationdefinition[GO:0001934]  
1
  • IDAUniProtKB
Positive regulation of renal albumin absorptiondefinition[GO:2000534]  
1
  • IDAUniProtKB
Positive regulation of signal transductiondefinition[GO:0009967]  
1
  • ISSBHF-UCL
Protein heterotrimerizationdefinition[GO:0070208] silver  
  • IEAOrtholog Compara
Protein homooligomerizationdefinition[GO:0051260]  
  • ISSOrtholog Curator
Protein localization to plasma membranedefinition[GO:0072659]  
1
  • IDAUniProtKB
Regulation of glucose metabolic processdefinition[GO:0010906]  
1
  • IDAUniProtKB
Response to activitydefinition[GO:0014823] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to glucosedefinition[GO:0009749]  
1
  • ISSBHF-UCL
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to linoleic aciddefinition[GO:0070543] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Response to sucrosedefinition[GO:0009744] silver  
  • IEAOrtholog Compara
Response to tumor necrosis factordefinition[GO:0034612]  
1
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Adipocytokine signaling pathway  hsa04920+9370  
PPAR signaling pathway  hsa03320+9370  
Type II diabetes mellitus  hsa04930+9370  
According to Reactome, this protein belongs to the following pathway:
Transcriptional regulation of white adipocyte differentiation  REACT_27161  
Note 
Variants Arg-84 and Ser-90 show impaired formation of HMW complexes whereas variants Cys-112 and Thr-164 show impaired secretion of adiponectin in any form.  
  • CuratedUniProtKB
HMW-complex blood contents are higher in females than in males, are increased in males by castration and decreased again upon subsequent testosterone treatment, which blocks HMW-complex secretion (By similarity). In type 2 diabetic patients, both the ratios of HMW to total adiponectin and the degree of adiponectin glycosylation are significantly decreased as compared with healthy controls.  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Hormone  definition   [KW-0372]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Adiponectin
GenomeRNAi: 9370
PRO: PR:Q15848