CACNA1E - Voltage-dependent R-type calcium channel subunit alpha-1E - human protein (Function)
 
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CACNA1E »  Voltage-dependent R-type calcium channel subunit alpha-1E
 
Protein also known as:  Calcium channel, L type, alpha-1 polypeptide, isoform 6.
Gene name:  CACNA1E
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega-conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.  
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  • UniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
1
  • InterPro 2 GO
High voltage-gated calcium channel activitydefinition[GO:0008331]  
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  • RefGenome
Voltage-gated calcium channel activitydefinition[GO:0005245]  
1
  • MGI
GO biological process 
Calcium ion importdefinition[GO:0070509]  
1
  • RefGenome
Calcium ion transmembrane transportdefinition[GO:0070588]  
1
  • UniProtKB KW
Membrane depolarization during action potentialdefinition[GO:0086010]  
1
  • RefGenome
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • UniProtKB KW
Synaptic transmissiondefinition[GO:0007268]  
1
  • RefGenome
Transportdefinition[GO:0006810]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+777  
MAPK signaling pathway  hsa04010+777  
Type II diabetes mellitus  hsa04930+777  
According to Reactome, this protein belongs to the following pathways:
Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels  REACT_13606  
Regulation of insulin secretion  REACT_18325  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Calcium channel  definition   [KW-0107]
Ion channel  definition   [KW-0407]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: R-type_calcium_channel
GenomeRNAi: 777
PRO: PR:Q15878
Chemistry
GuidetoPHARMACOLOGY: 534