SNCB - Beta-synuclein - human protein (Function)
 
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Protein
Gene
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SNCB »  Beta-synuclein
 
Gene name:  SNCB
Family name: Synuclein
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.  
  • CuratedUniProtKB
GO molecular function 
Alpha-tubulin bindingdefinition[GO:0043014] silver  
  • IEAOrtholog Compara
Beta-tubulin bindingdefinition[GO:0048487] silver  
  • IEAOrtholog Compara
Calcium ion bindingdefinition[GO:0005509]  
1
  • IDAUniProtKB
Phospholipase inhibitor activitydefinition[GO:0004859]  
1
  • TASPINC
GO biological process 
Dopamine metabolic processdefinition[GO:0042417] silver  
  • IEAOrtholog Compara
Negative regulation of catalytic activitydefinition[GO:0043086]  
1
  • TASGOC
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Regulation of catalytic activitydefinition[GO:0050790]  
1
  • TASGOC
Synapse organizationdefinition[GO:0050808] silver  
  • IEAOrtholog Compara
Synaptic transmissiondefinition[GO:0007268] silver  
  • IEAOrtholog Compara
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Beta-synuclein
GenomeRNAi: 6620
PRO: PR:Q16143