E2F4 - Transcription factor E2F4 - human protein (Function)
 
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E2F4 »  Transcription factor E2F4  (E2F-4)
 
Gene name:  E2F4
Family name: E2F/DP
Entry whose protein(s) existence is based on evidence at protein level
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1 56 1
GENE REF ISO

Function

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Overview 
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1.  
  • CuratedUniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • IMPUniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • IPIUniProtKB
  • IPIIntAct
Protein domain specific bindingdefinition[GO:0019904]  
1
  • IPIUniProtKB
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • IDAUniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • IPIUniProtKB
GO biological process 
Blood circulationdefinition[GO:0008015] silver  
  • IEAOrtholog Compara
Cell volume homeostasisdefinition[GO:0006884] silver  
  • IEAOrtholog Compara
Cilium assemblydefinition[GO:0042384] silver  
  • IEAOrtholog Compara
Epithelial cell developmentdefinition[GO:0002064] silver  
  • IEAOrtholog Compara
Organ morphogenesisdefinition[GO:0009887] silver  
  • IEAOrtholog Compara
Regulation of cell proliferationdefinition[GO:0042127] silver  
  • IEAOrtholog Compara
Regulation of cell sizedefinition[GO:0008361] silver  
  • IEAOrtholog Compara
Regulation of transcription involved in G1/S transition of mitotic cell cycledefinition[GO:0000083] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell cycle  hsa04110+1874  
TGF-beta signaling pathway  hsa04350+1874  
According to Reactome, this protein belongs to the following pathways:
Cell Cycle  REACT_115566  
Disease  REACT_116125  
Gene Expression  REACT_71  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: E2F4
GenomeRNAi: 1874
PRO: PR:Q16254