E2F4 - Transcription factor E2F4 - human protein (Function)
 
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E2F4 »  Transcription factor E2F4  (E2F-4)
 
Gene name:  E2F4
Family name: E2F/DP
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis.  
4
  • UniProtKB
GO molecular function 
DNA bindingdefinition[GO:0003677]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
6
  • UniProtKB
  • IntAct
Protein domain specific bindingdefinition[GO:0019904]  
1
  • UniProtKB
RNA polymerase II core promoter proximal region sequence-specific DNA bindingdefinition[GO:0000978]  
1
  • NTNU_SB
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptiondefinition[GO:0001077]  
1
  • GO curators
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
1
  • UniProtKB
Transcription factor bindingdefinition[GO:0008134]  
1
  • UniProtKB
GO biological process 
Blood circulationdefinition[GO:0008015] silver  
1
  • Ortholog Compara
Cell volume homeostasisdefinition[GO:0006884] silver  
1
  • Ortholog Compara
Centriole assemblydefinition[GO:0098534]  
1
  • Ortholog Curator
Epithelial cell developmentdefinition[GO:0002064] silver  
1
  • Ortholog Compara
Motile cilium assemblydefinition[GO:0044458]  
1
  • Ortholog Curator
Multi-ciliated epithelial cell differentiationdefinition[GO:1903251]  
1
  • Ortholog Curator
Organ morphogenesisdefinition[GO:0009887] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • NTNU_SB
  • Ortholog Curator
Regulation of cell proliferationdefinition[GO:0042127] silver  
1
  • Ortholog Compara
Regulation of cell sizedefinition[GO:0008361] silver  
1
  • Ortholog Compara
Regulation of transcription involved in G1/S transition of mitotic cell cycledefinition[GO:0000083] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cell cycle  hsa04110+1874  
TGF-beta signaling pathway  hsa04350+1874  
According to Reactome, this protein belongs to the following pathways:
Cyclin D associated events in G1  REACT_821  
G0 and Early G1  REACT_111214  
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription  REACT_120734  
 

Keywords

Biological process 
Cell cycle  definition   [KW-0131]
Cilium biogenesis/degradation  definition   [KW-0970]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: E2F4
GenomeRNAi: 1874
PRO: PR:Q16254