IGFBP7 - Insulin-like growth factor-binding protein 7 - human protein (Function)
 
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IGFBP7 »  Insulin-like growth factor-binding protein 7  (IBP-7)
 
Protein also known as:  Prostacyclin-stimulating factor.
Gene name:  IGFBP7
Entry whose protein(s) existence is based on evidence at protein level
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1 74 2
GENE REF ISO

Function

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Overview 
Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.  
2
  • CuratedUniProtKB
GO molecular function 
Insulin-like growth factor bindingdefinition[GO:0005520] silver  
  • IEAInterPro 2 GO
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
GO biological process 
Cell adhesiondefinition[GO:0007155]  
1
  • IDAUniProtKB
Cellular response to hormone stimulusdefinition[GO:0032870] silver  
  • IEAOrtholog Compara
Embryo implantationdefinition[GO:0007566] silver  
  • IEAOrtholog Compara
Inner ear developmentdefinition[GO:0048839] silver  
  • IEAOrtholog Compara
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • TASPINC
Regulation of cell growthdefinition[GO:0001558] silver  
  • IEAInterPro 2 GO
Regulation of steroid biosynthetic processdefinition[GO:0050810] silver  
  • IEAOrtholog Compara
Response to cortisoldefinition[GO:0051414] silver  
  • IEAOrtholog Compara
Response to heatdefinition[GO:0009408] silver  
  • IEAOrtholog Compara
Response to retinoic aciddefinition[GO:0032526] silver  
  • IEAOrtholog Compara
Enzymatic activity 
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathway:
Cellular responses to stress  REACT_120956  
 

Keywords

Biological process 
Cell adhesion  definition   [KW-0130]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: IGFBP7
GenomeRNAi: 3490
PRO: PR:Q16270