CNGA3 - Cyclic nucleotide-gated cation channel alpha-3 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
CNGA3 »  Cyclic nucleotide-gated cation channel alpha-3
 
Protein also known as:  Cone photoreceptor cGMP-gated channel subunit alpha.
Gene name:  CNGA3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 50 2
GENE REF ISO

Function

 show evidences
Overview 
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.5.12  
GO molecular function 
cGMP bindingdefinition[GO:0030553] silver  
  • IBARefGenome
Intracellular cAMP activated cation channel activitydefinition[GO:0005222] silver  
  • IBARefGenome
Intracellular cGMP activated cation channel activitydefinition[GO:0005223] silver  
  • IBARefGenome
Ligand-gated ion channel activitydefinition[GO:0015276]  
1
  • TASPINC
Voltage-gated potassium channel activitydefinition[GO:0005249] silver  
  • IBARefGenome
GO biological process 
Phototransduction, visible lightdefinition[GO:0007603] silver  
  • IBARefGenome
Potassium ion transmembrane transportdefinition[GO:0071805] silver  
  • IBARefGenome
Regulation of ion transmembrane transportdefinition[GO:0034765] silver  
  • IBARefGenome
Regulation of membrane potentialdefinition[GO:0042391] silver  
  • IBARefGenome
Regulation of transportdefinition[GO:0051049] silver  
  • IBARefGenome
Response to cAMPdefinition[GO:0051591] silver  
  • IEAOrtholog Compara
Response to corticosteroiddefinition[GO:0031960] silver  
  • IEAOrtholog Compara
Response to magnesium iondefinition[GO:0032026] silver  
  • IEAOrtholog Compara
Retinal cone cell developmentdefinition[GO:0046549] silver  
  • IEAOrtholog Compara
Signal transductiondefinition[GO:0007165]  
1
  • TASPINC
Transportdefinition[GO:0006810]  
1
  • TASPINC
Visual perceptiondefinition[GO:0007601]  
  • IEAUniProtKB KW
Pathways 
According to KEGG, this protein belongs to the following pathway:
Olfactory transduction  hsa04740+1261  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sensory transduction  definition   [KW-0716]
Transport  definition   [KW-0813]
Vision  definition   [KW-0844]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Cyclic_nucleotide-gated_channel_alpha_3
GenomeRNAi: 1261
PRO: PR:Q16281
Chemistry
GuidetoPHARMACOLOGY: 396