GRIK5 - Glutamate receptor ionotropic, kainate 5 - human protein (Function)
 
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GRIK5 »  Glutamate receptor ionotropic, kainate 5  (GluK5)
 
Protein also known as:  Excitatory amino acid receptor 2 (EAA2).
Gene name:  GRIK5
Entry whose protein(s) existence is based on evidence at transcript level
extend overview
1 26 2
GENE REF ISO

Function

 show evidences
Overview 
Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L-glutamate >> AMPA >> NMDA = 1S,3R-ACPD.  
  • CuratedUniProtKB
GO molecular function 
Extracellular-glutamate-gated ion channel activitydefinition[GO:0005234] silver  
  • IBARefGenome
Identical protein bindingdefinition[GO:0042802] silver  
  • IEAOrtholog Compara
Kainate selective glutamate receptor activitydefinition[GO:0015277]  
1
  • IDAUniProtKB
PDZ domain bindingdefinition[GO:0030165] silver  
  • IEAOrtholog Compara
SH3 domain bindingdefinition[GO:0017124] silver  
  • IEAOrtholog Compara
GO biological process 
Cellular response to glucose stimulusdefinition[GO:0071333] silver  
  • IEAOrtholog Compara
Establishment of localization in celldefinition[GO:0051649] silver  
  • IEAOrtholog Compara
Ion transmembrane transportdefinition[GO:0034220] silver  
  • IBARefGenome
Ionotropic glutamate receptor signaling pathwaydefinition[GO:0035235]  
1
  • IDAGOC
Positive regulation of neuron apoptotic processdefinition[GO:0043525] silver  
  • IEAOrtholog Compara
Protein retention in ER lumendefinition[GO:0006621] silver  
  • IEAOrtholog Compara
Receptor clusteringdefinition[GO:0043113] silver  
  • IEAOrtholog Compara
Regulation of excitatory postsynaptic membrane potentialdefinition[GO:0060079] silver  
  • IEAOrtholog Compara
Regulation of synaptic vesicle fusion to presynaptic membranedefinition[GO:0031630] silver  
  • IEAOrtholog Compara
Synaptic transmission, glutamatergicdefinition[GO:0035249] silver  
  • IBARefGenome
Pathways 
According to KEGG, this protein belongs to the following pathways:
Glutamatergic synapse  hsa04724+2901  
Neuroactive ligand-receptor interaction  hsa04080+2901  
According to Reactome, this protein belongs to the following pathway:
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: GRIK5
GenomeRNAi: 2901
PRO: PR:Q16478
Chemistry
GuidetoPHARMACOLOGY: 454