PKN2 - Serine/threonine-protein kinase N2 - human protein (Function)
 
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PKN2 »  Serine/threonine-protein kinase N2   [ EC 2.7.11.13 ]
 
Protein also known as:  Protein-kinase C-related kinase 2.
Gene name:  PKN2
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 51 5
GENE REF ISO

Function

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Overview 
PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.  
10
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Histone deacetylase bindingdefinition[GO:0042826]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IPIUniProtKB
  • IPIIntAct
Protein kinase activitydefinition[GO:0004672]  
1
  • TASPINC
Protein kinase C activitydefinition[GO:0004697]  
  • IEAEC 2 GO
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
GO biological process 
Apical junction assemblydefinition[GO:0043297]  
1
  • IMPUniProtKB
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Cell adhesiondefinition[GO:0007155]  
  • IEAUniProtKB KW
Cell cycledefinition[GO:0007049]  
  • IEAUniProtKB KW
Cell divisiondefinition[GO:0051301]  
  • IEAUniProtKB KW
Epithelial cell migrationdefinition[GO:0010631]  
1
  • IDAUniProtKB
Positive regulation of cytokinesisdefinition[GO:0032467]  
1
  • IMPUniProtKB
Positive regulation of mitotic cell cycledefinition[GO:0045931]  
1
  • IMPUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Regulation of cell motilitydefinition[GO:2000145]  
1
  • IMPUniProtKB
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
Signal transductiondefinition[GO:0007165] silver  
  • IEAInterPro 2 GO
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.13: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Kinase activity is activated upon binding to GTP-bound Rhoa/Rac1 GTPases. Activated by caspase-3 (CASP3) cleavage during apoptosis. Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids and unsaturated fatty acids. Two specific sites, Thr-816 (activation loop of the kinase domain) and Thr-958 (turn motif), need to be phosphorylated for its full activation.  
3
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Salmonella infection  hsa05132+5586  
 

Biophysicochemical properties

Kinetic parameters
KM 15.83 uM for HDAC5

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Cell adhesion  definition   [KW-0130]
Cell cycle  definition   [KW-0131]
Cell division  definition   [KW-0132]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PKN2
GenomeRNAi: 5586
PRO: PR:Q16513
Chemistry
GuidetoPHARMACOLOGY: 1521