ASIC2 - Acid-sensing ion channel 2 - human protein (Function)
 
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ASIC2 »  Acid-sensing ion channel 2  (ASIC2)
 
Protein also known as:  Amiloride-sensitive cation channel 1, neuronal.
Gene name:  ASIC2
Entry whose protein(s) existence is based on evidence at protein level
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1 23 2
GENE REF ISO

Function

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Overview 
Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.  
1
  • UniProtKB
GO molecular function 
Ion gated channel activitydefinition[GO:0022839] silver  
1
  • Ortholog Compara
Ligand-gated sodium channel activitydefinition[GO:0015280] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
Voltage-gated sodium channel activitydefinition[GO:0005248] silver  
1
  • Ortholog Compara
GO biological process 
Cellular response to acid chemicaldefinition[GO:0071229] silver  
1
  • Ortholog Compara
Cellular response to acidic pHdefinition[GO:0071468] silver  
1
  • Ortholog Compara
Central nervous system developmentdefinition[GO:0007417]  
1
  • PINC
Detection of mechanical stimulus involved in sensory perceptiondefinition[GO:0050974] silver  
1
  • Ortholog Compara
Monovalent inorganic cation transportdefinition[GO:0015672]  
1
  • PINC
Negative regulation of apoptotic processdefinition[GO:0043066] silver  
1
  • Ortholog Compara
Peripheral nervous system developmentdefinition[GO:0007422]  
1
  • PINC
Phototransductiondefinition[GO:0007602] silver  
1
  • Ortholog Compara
Positive regulation of cation channel activitydefinition[GO:2001259] silver  
1
  • Ortholog Compara
Positive regulation of synapse assemblydefinition[GO:0051965] silver  
1
  • Ortholog Compara
Protein localization to synapsedefinition[GO:0035418] silver  
1
  • Ortholog Compara
Regulation of blood coagulationdefinition[GO:0030193]  
1
  • UniProtKB
Regulation of gene expressiondefinition[GO:0010468]  
1
  • UniProtKB
Regulation of membrane potentialdefinition[GO:0042391] silver  
1
  • Ortholog Compara
Regulation of systemic arterial blood pressure by aortic arch baroreceptor feedbackdefinition[GO:0003026] silver  
1
  • Ortholog Compara
Regulation of vasoconstrictiondefinition[GO:0019229] silver  
1
  • Ortholog Compara
Sensory perception of sounddefinition[GO:0007605] silver  
1
  • Ortholog Compara
Sensory perception of sour tastedefinition[GO:0050915]  
1
  • UniProtKB
Sodium ion transmembrane transportdefinition[GO:0035725]  
4
  • GOC
  • InterPro 2 GO
  • Ortholog Compara
  • UniProtKB KW
Synaptic transmissiondefinition[GO:0007268]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathway:
Taste transduction  hsa04742+40  
According to Reactome, this protein belongs to the following pathway:
Stimuli-sensing channels  REACT_160189  
Note 
Inhibited by anti-inflammatory drugs like salicylic acid (By similarity). Regulated by Zn(2+).  
1
  • UniProtKB
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Sodium transport  definition   [KW-0739]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Sodium channel  definition   [KW-0894]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ACCN1
GenomeRNAi: 40
PRO: PR:Q16515
Chemistry
GuidetoPHARMACOLOGY: 685