BATF - Basic leucine zipper transcriptional factor ATF-like - human protein (Function)
 
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BATF »  Basic leucine zipper transcriptional factor ATF-like
 
Protein also known as:  B-cell-activating transcription factor (B-ATF).
Gene name:  BATF
Family name: bZIP
Entry whose protein(s) existence is based on evidence at protein level
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Function

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Overview 
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).  
  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
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  • IPIUniProtKB
Sequence-specific DNA bindingdefinition[GO:0043565]  
  • ISSOrtholog Curator
Sequence-specific DNA binding transcription factor activitydefinition[GO:0003700]  
  • ISSOrtholog Curator
GO biological process 
Cellular response to DNA damage stimulusdefinition[GO:0006974]  
  • ISSOrtholog Curator
Cytokine productiondefinition[GO:0001816]  
  • ISSOrtholog Curator
Defense response to protozoandefinition[GO:0042832]  
  • ISSOrtholog Curator
DNA damage response, signal transduction by p53 class mediatordefinition[GO:0030330]  
  • ISSOrtholog Curator
Hematopoietic stem cell differentiationdefinition[GO:0060218]  
  • ISSOrtholog Curator
Isotype switchingdefinition[GO:0045190]  
  • ISSOrtholog Curator
Lymphoid progenitor cell differentiationdefinition[GO:0002320]  
  • ISSOrtholog Curator
Myeloid dendritic cell differentiationdefinition[GO:0043011]  
  • ISSOrtholog Curator
Regulation of transcription, DNA-templateddefinition[GO:0006355]  
  • IEAUniProtKB KW
T-helper 17 cell differentiationdefinition[GO:0072539]  
  • ISSOrtholog Curator
T-helper 17 cell lineage commitmentdefinition[GO:0072540]  
  • ISSOrtholog Curator
T-helper 2 cell differentiationdefinition[GO:0045064]  
  • ISSOrtholog Curator
Transcription, DNA-templateddefinition[GO:0006351]  
  • IEAUniProtKB KW
 

Keywords

Biological process 
Differentiation  definition   [KW-0221]
Transcription  definition   [KW-0804]
Transcription regulation  definition   [KW-0805]
Molecular function 
Activator  definition   [KW-0010]
Repressor  definition   [KW-0678]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: BATF_(gene)
GenomeRNAi: 10538
PRO: PR:Q16520