KCNMB1 - Calcium-activated potassium channel subunit beta-1 - human protein (Function)
 
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Protein
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KCNMB1 »  Calcium-activated potassium channel subunit beta-1
 
Protein also known as:  Calcium-activated potassium channel, subfamily M subunit beta-1 (Calcium-activated potassium channel subunit beta).
Gene name:  KCNMB1
Family name: KCNMB (TC 8.A.14.1) » KCNMB1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 43 2
GENE REF ISO

Function

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Overview 
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the ca(2+)-activated k(+) channel auxiliary subunit slowpoke- (slo) family  8.A.14.1.2  
GO molecular function 
Calcium-activated potassium channel activitydefinition[GO:0015269] silver  
  • IEAOrtholog Compara
Potassium channel regulator activitydefinition[GO:0015459] silver  
  • IEAOrtholog Compara
GO biological process 
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • TASGOC
  • IEAOrtholog Compara
  • IEAInterPro 2 GO
Potassium ion transportdefinition[GO:0006813]  
1
  • TASPINC
Response to calcium iondefinition[GO:0051592] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Vascular smooth muscle contraction  hsa04270+3779  
According to Reactome, this protein belongs to the following pathways:
Ca2+ activated K+ channels  REACT_75896  
cGMP effects  REACT_23767  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KCNMB1
GenomeRNAi: 3779
PRO: PR:Q16558