DARC - Duffy antigen/chemokine receptor - human protein (Function)
 
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DARC »  Duffy antigen/chemokine receptor
 
Protein also known as:  Atypical chemokine receptor 1; CD antigen CD234.
Gene name:  DARC
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 81 2
GENE REF ISO

Function

 show evidences
Overview 
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.  
  • CuratedUniProtKB
GO molecular function 
C-C chemokine bindingdefinition[GO:0019957]  
1
  • IPIBHF-UCL
G-protein coupled receptor activitydefinition[GO:0004930]  
  • IEAUniProtKB KW
Receptor activitydefinition[GO:0004872]  
1
  • TASPINC
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • TASPINC
GO biological process 
Chemokine-mediated signaling pathwaydefinition[GO:0070098] silver  
  • IEAInterPro 2 GO
Defense responsedefinition[GO:0006952]  
1
  • NASUniProtKB
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Regulation of chemokine productiondefinition[GO:0032642] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Malaria  hsa05144+2532  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Blood group antigen  definition   [KW-0095]
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Duffy_antigen_system
GenomeRNAi: 2532
PRO: PR:Q16570