C3AR1 - C3a anaphylatoxin chemotactic receptor - human protein (Function)
 
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C3AR1 »  C3a anaphylatoxin chemotactic receptor  (C3AR)
 
Gene name:  C3AR1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.  
1
  • UniProtKB
GO molecular function 
C3a anaphylatoxin receptor activitydefinition[GO:0004943] silver  
1
  • Ortholog Compara
Complement component C3a bindingdefinition[GO:0001850] silver  
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  • Ortholog Compara
Complement component C3a receptor activitydefinition[GO:0004876]  
1
  • PINC
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • UniProtKB
Phosphatidylinositol phospholipase C activitydefinition[GO:0004435]  
1
  • PINC
GO biological process 
Blood circulationdefinition[GO:0008015]  
1
  • PINC
Chemotaxisdefinition[GO:0006935]  
1
  • UniProtKB KW
Complement receptor mediated signaling pathwaydefinition[GO:0002430] silver  
1
  • Ortholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • UniProtKB KW
Inflammatory responsedefinition[GO:0006954]  
1
  • PINC
Positive regulation of angiogenesisdefinition[GO:0045766] silver  
1
  • Ortholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204]  
1
  • UniProtKB
Positive regulation of DNA biosynthetic processdefinition[GO:2000573] silver  
1
  • Ortholog Compara
Positive regulation of glomerular mesangial cell proliferationdefinition[GO:0072126] silver  
1
  • Ortholog Compara
Positive regulation of macrophage chemotaxisdefinition[GO:0010759] silver  
1
  • Ortholog Compara
Positive regulation of neutrophil chemotaxisdefinition[GO:0090023] silver  
1
  • Ortholog Compara
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661] silver  
1
  • Ortholog Compara
Positive regulation of vascular endothelial growth factor productiondefinition[GO:0010575] silver  
1
  • Ortholog Compara
Regulation of blood pressuredefinition[GO:0008217] silver  
1
  • Ortholog Compara
Tolerance induction to nonself antigendefinition[GO:0002462] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Complement and coagulation cascades  hsa04610+719  
Neuroactive ligand-receptor interaction  hsa04080+719  
Staphylococcus aureus infection  hsa05150+719  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  R-HSA-418594  
Peptide ligand-binding receptors  R-HSA-375276  
 

Keywords

Biological process 
Chemotaxis  definition   [KW-0145]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: C3a_receptor
GenomeRNAi: 719
PRO: PR:Q16581
Chemistry
GuidetoPHARMACOLOGY: 31