MAP3K11 - Mitogen-activated protein kinase kinase kinase 11 - human protein (Function)
 
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MAP3K11 »  Mitogen-activated protein kinase kinase kinase 11   [ EC 2.7.11.25 ]
 
Protein also known as:  Src-homology 3 domain-containing proline-rich kinase.
Gene name:  MAP3K11
Entry whose protein(s) existence is based on evidence at protein level
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1 68 1
GENE REF ISO

Function

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Overview 
Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.  
4
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524] silver  
  • IEAOrtholog Compara
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIUniProtKB
JUN kinase kinase kinase activitydefinition[GO:0004706]  
  • ISSOrtholog Curator
Mitogen-activated protein kinase kinase bindingdefinition[GO:0031434] silver  
  • IEAOrtholog Compara
Mitogen-activated protein kinase kinase kinase bindingdefinition[GO:0031435]  
1
  • IPIUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
Protein kinase activitydefinition[GO:0004672]  
2
  • TASPINC
Protein serine/threonine kinase activitydefinition[GO:0004674]  
1
  • IDAUniProtKB
Protein tyrosine kinase activitydefinition[GO:0004713] silver  
  • IEAInterPro 2 GO
Rac GTPase bindingdefinition[GO:0048365] silver  
  • IEAOrtholog Compara
GO biological process 
Activation of JNKK activitydefinition[GO:0007256] silver  
  • IEAOrtholog Compara
Activation of JUN kinase activitydefinition[GO:0007257]  
1
  • IMPUniProtKB
Activation of MAPK activitydefinition[GO:0000187]  
1
  • IMPUniProtKB
Cell deathdefinition[GO:0008219] silver  
  • IEAOrtholog Compara
Cell proliferationdefinition[GO:0008283]  
1
  • IMPUniProtKB
JNK cascadedefinition[GO:0007254]  
1
  • TASPINC
Microtubule-based processdefinition[GO:0007017]  
1
  • IMPUniProtKB
Mitotic G1 phasedefinition[GO:0000080]  
1
  • IMPUniProtKB
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
  • IEAInterPro 2 GO
Positive regulation of JNK cascadedefinition[GO:0046330]  
1
  • IMPUniProtKB
Positive regulation of JUN kinase activitydefinition[GO:0043507]  
1
  • IMPUniProtKB
Positive regulation of neuron apoptotic processdefinition[GO:0043525] silver  
  • IEAOrtholog Compara
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAUniProtKB
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.25: ATP + a protein ADP + a phosphoprotein.  
1
  • CuratedUniProtKB
It requires the following cofactor
Magnesium (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.  
2
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
MAPK signaling pathway  hsa04010+4296  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MAP3K11
GenomeRNAi: 4296
PRO: PR:Q16584
Chemistry
GuidetoPHARMACOLOGY: 2071